Results 41 to 50 of about 5,217,878 (218)

An externally validated age-related model of mean follicle density in the cortex of the human ovary [PDF]

, 2015
The population of non-growing follicles present in the ovary is defined as the ovarian reserve. This underpins the reproductive lifespan in women, with its depletion determining age at loss of fertility and the menopause.
Kelsey, Tom, R. A. Anderson, W. H. B. Wallace, E. E. Telfer, Wallace, W Hamish B, Kelsey, T W, Telfer, E E, McLaughlin, M, Anderson, Richard A, Wallace, Hamish, T. W. Kelsey, M. McLaughlin, McLaughlin, Marie, Telfer, Evelyn E, Anderson, R A, Kelsey, Tom; id_orcid   +15 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Responses of belowground fine root biomass and morphology in Robinia pseudoacacia L. plantations to aboveground environmental factors

Global Ecology and Conservation
The adaptation of fine roots to a variety of environmental conditions is crucial for promoting the growth and long-term survival of forest trees. To achieve sustainable forest ecology management requires a comprehensive understanding of the intricate ...
Yonghan Feng, Xiang Sui, Jie Tang, Rui Liu, Xile Ling, Wenjun Liang, Xi Wei   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Bovine pericardium based non-cross linked collagen matrix for successful root coverage, a clinical study in human [PDF]

, 2012
Introduction: The aim of this study was to clinically assess the capacity of a novel bovine pericardium based, non-cross linked collagen matrix in root coverage. Methods: 62 gingival recessions of Miller class I or II were treated.
Sculean Anton, Sader Robert A, Willershausen Ines, Shahram Ghanaati, Ines Willershausen, Ghanaati, Shahram Michael, Anton Sculean, Ghanaati Shahram, Robert A. Sader, Sader, Robert A, Schlee, Markus, Sader, Robert Alexander, Stimmlmayr Michael, Schlee Markus, Markus Schlee, Sculean, Anton, Ghanaati, Shahram, Willershausen, Ines, Willershausen, Ines Bettina Anne, Stimmlmayr, Michael, Michael Stimmlmayr, Sader, Robert A.   +21 more
core   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Data of first-order root trait in eastern China

, 2017
The data file contains six first-order root traits, including root diameter (RD), specific root length (SRL), root tissue density (RTD), root carbon and nitrogen concentration (RC and RN) and C:N ratio, of 181 plant species from eight subtropical and ...
Xianjin Zhu (572546), Zhao, Ning, Zhu, Xianjin, Wang, Qiufeng, Qiufeng Wang (553607), Ning Zhao (84707), Xu, Zhiwei, Guirui Yu (326316), Yu, Guirui, Zhiwei Xu (294494), Jiao, Cui, Ruili Wang (303054), Nianpeng He (140644), He, Nianpeng, Wang, Ruili, Cui Jiao (5028224)   +15 more
core   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source