Results 31 to 40 of about 115,623 (217)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Phenotyping, genome‐wide dissection, and prediction of maize root architecture for temperate adaptability

iMeta
Root System Architecture (RSA) plays an essential role in influencing maize yield by enhancing anchorage and nutrient uptake. Analyzing maize RSA dynamics holds potential for ideotype‐based breeding and prediction, given the limited understanding of the ...
Weijun Guo, Fanhua Wang, Jianyue Lv, Jia Yu, Yue Wu, Hada Wuriyanghan, Liang Le, Li Pu   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Comprehensive phenotyping of SKUAST-K released rice varieties reveals significant role of root traits in drought resilience

Discover Agriculture
The North Western Himalayan region, particularly the Kashmir valley, harbors a rich diversity of rice landraces, yet systematic studies on climate resilience are lacking.
Sadiah Shafi, Aaqif Zaffar, Ishrat Riyaz, Mohan Raj, Bisma Jan, Sajad Majeed Zargar, S Gurumurthy, Asif B. Shikari, N. R. Sofi, P. V. Vara Prasad, Parvaze A. Sofi   +10 more
doaj   +1 more source

Elucidating the genomic regions through genome-wide association study (GWAS) for root traits in cowpea (Vigna unguiculata (L) Walp) mini-core collection

Plant Stress
Enhancing the root traits through selection and breeding efforts can significantly improve the acquisition of soil resources, consequently boosting crop production in marginal environments.
Aaqif Zaffar, Rajneesh Paliwal, Michael Abberton, Sabina Akhtar, Rafiq Ahmad Mengnoo, Aamir Nazir Sheikh, Parvaze Ahmad Sofi, Mohd Ashraf Bhat, Reyazul Rouf Mir   +8 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Studies on root traits for drought tolerance in aerobic rice (Oryza sativa L.) using polythene bags

Electronic Journal of Plant Breeding, 2017
The present investigation was carried out under aerobic condition to evaluate twenty five genotypes for drought tolerance potentiality conferred by root traits.
M. Vengatesh and, R. Govindarasu
doaj   +1 more source

Plant Nutrient Contents Rather Than Physical Traits Are Coordinated Between Leaves and Roots in a Desert Shrubland

Frontiers in Plant Science, 2021
Although leaf economics spectrum (LES) has been extensively tested with regional and global datasets, the correlation among functional traits of desert plants remains largely unclear.
Xiaoyan Jiang, Xin Jia, Xin Jia, Shengjie Gao, Yan Jiang, Ningning Wei, Cong Han, Tianshan Zha, Tianshan Zha, Peng Liu, Peng Liu, Yun Tian, Shugao Qin, Shugao Qin   +13 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source