Results 51 to 60 of about 50,388 (312)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The Effect of Hormone Treatment on the Rooting of Leyland Cypress Cuttings [PDF]
This study explored the effects of indole butyric acid treatment on the vegetative propagation (cuttings) of Leyland cypress at different rates and periods in two experiments. Cutting materials were obtained from mother trees growing in the nursery.
Çetin, B., Bilal Çetin
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Relationship between rooting stage of Malus hupehensis cuttings and rooting percentage.
, 2017 A: Effects of different exogenous hormones on rooting percentage and rooting stage of Malus hupehensis cuttings, B: Correlation between different rooting stages and rooting percentage. P0 represents the date when cuttings were planted. S1 is the root pre-
Qianqian Tan (3775384) +5 more
core +1 more source
Root Polytopes and Growth Series of Root Lattices [PDF]
SIAM Journal on Discrete Mathematics, 2011 17 pages, 3 ...
Ardila, Federico +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Cyclic predisposition to adventitious rooting in young and adult branch tissues in two olive genotypes: molecular analysis [PDF]
, 2022 openLa predisposizione ontogenetica è intrinseca agli organismi viventi e guida i ritmi e i tempi degli eventi morfologici che appaiono nel corso della vita.
PESCATORE, MARTINA
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source