Results 111 to 120 of about 2,477,378 (287)

Diversification of Cultivars and Production of Male Inflorescence Flours for More Sustainable Banana Cultivation

open access: yesAgriculture
Banana inflorescences are usually discarded, but there has been interest in managing this by-product to turn it into a product with added value.
Lucas Felipe dos Ouros   +8 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

The Dark Shadows: Unraveling the Impact of Supervisor Bottom Line Mentality on Workplace Jealousy Through Job Insecurity and Resilience

open access: yesSAGE Open
Supervisor BLM is referred to as a unidimensional frame of mind that revolves around the attainment of bottom-line outcomes; this mentality is commonly found in today’s organizations.
Sehrish Munaf, Amir Gulzar, Hina Fayyaz
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

When do people want to retire? The preferred retirement age gap between Eastern and Western Europe explained

open access: yesStudies of Transition States and Societies, 2016
Debates surrounding working longer focus mainly on increasing legal and effective retirement ages, leaving the preferred retirement age largely overlooked.
Wouter de Tavernier, Ave Roots
doaj  

Allocation Patterns and Strategies of Carbon, Nitrogen, and Phosphorus Densities in Three Typical Desert Plants

open access: yesPlants
The densities of carbon, nitrogen, and phosphorus (C-N-P) reflect the adaptation and response of desert plants to hyper-arid environments. However, the allocation strategies for biomass and C-N-P densities among various plant life forms remain poorly ...
Guangxing Zhao   +10 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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