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AEG-1 as a Novel Therapeutic Target in Colon Cancer: A Study from Silencing AEG-1 in BALB/c Mice to Large Data Analysis.

Current Gene Therapy
BACKGROUND Astrocyte elevated gene-1 (AEG-1) is overexpressed in various malignancies. Exostosin-1 (EXT-1), a tumor suppressor, is an intermediate for malignant tumors.
Sushmitha Sriramulu   +10 more
semanticscholar   +1 more source

Brine shrimp Artemia salina to evaluate the impact of environmental concentrations of BMAA and isomers, DAB and AEG, via mortality (nauplii) and behavioural (adult) tests.

Science of the Total Environment
BMAA and its isomers, DAB and AEG, are toxins mainly produced by cyanobacterial blooms and represent an emerging risk worldwide. Anthropization and climate changes are expanding blooms and the presence of these toxins has been evidenced in different ...
J. Lichtfouse   +3 more
semanticscholar   +1 more source

mRNA-seq-based analysis predicts: AEG-1 is a therapeutic target and immunotherapy biomarker for pan-cancer, including OSCC

Frontiers in Immunology
Background The aberrant expression of AEG-1 is significantly correlated with tumorigenesis, development, neurodegeneration and inflammation. However, the relationship between AEG-1 expression and immune infiltration in OSCC, as well as other tumor types,
Lihong Yao   +8 more
semanticscholar   +1 more source

Reactive astrogliosis induced by TNF-α is associated with upregulated AEG-1 together with activated NF-κB pathway in vitro.

Neuroscience Letters
Astrocyte-elevated gene-1 (AEG-1/MTDH/LYRIC) has garnered signficant attention in cancer research, yet, its role in inflammation-associated astrogliosis remains underexplored.
Juanjuan Li   +7 more
semanticscholar   +1 more source

Rootsi aeg eesti ajalookirjanduses aa. 1934-1938 :"mustandkäsikiri"

2022
Digiteeritud Rahvusarhiivi koordineeritud MKMi rahastatud SF-projekti „Vaba rahvas vabal maal (1920-1940)“ raames OÜ Andmevara Services ...
openaire   +1 more source

AEG-PPIS: A Dual-Branch Protein-protein Interaction Site Predictor Based on Augmented Graph Attention Network and Equivariant Graph Neural Network

IEEE International Conference on Bioinformatics and Biomedicine
The identification of protein-protein interaction sites (PPIS) plays a crucial role in understanding the mechanisms of biological processes. Traditional biological experimental methods for PPIS prediction are both expensive and time-consuming, developing
Huanhuan Dai   +5 more
semanticscholar   +1 more source

MicroRNA‐520e targets AEG‐1 to suppress the proliferation and invasion of colorectal cancer cells through Wnt/GSK‐3β/β‐catenin signalling

Clinical and Experimental Pharmacology and Physiology, 2020
MicroRNA‐520e (miR‐520e) is increasingly being recognized as a cancer‐related miRNA in multiple cancer types; however, little is known about its role in colorectal cancer.
Samei Lv   +7 more
semanticscholar   +1 more source

A Review on AEG-1 oncogene regulating MicroRNA expression in Colon Cancer progression.

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2020
MicroRNAs (miRS) are a class of small non-coding RNAs which perform a crucial function in posttranscriptional gene regulation. Dysregulation of this microRNAs are associated with many types of cancer progression. In tumorigenesis, downregulated microRNAs
Sarubala Malayaperumal   +4 more
semanticscholar   +1 more source

AEG-1 on cancer drug resistance: From molecular insights to therapeutic challenges.

Advances in Cancer Research
Wali Ullah   +5 more
semanticscholar   +1 more source

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