Results 31 to 40 of about 4,539 (66)

Metadherin (AEG-1/MTDH/LYRIC) expression: Significance in malignancy and crucial role in colorectal cancer.

Advances in Clinical Chemistry, 2022
Metadherin (AEG-1/MTDH/LYRIC) is a 582-amino acid transmembrane protein, encoded by a gene located at chromosome 8q22, and distributed throughout the cytoplasm, peri-nuclear region, nucleus, and nucleolus as well as the endoplasmic reticulum (ER).
Muhammad Tarek Abdel Ghafar, N. Soliman
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The absence of cellular glucose triggers oncogene AEG-1 that instigates VEGFC in HCC: A possible genetic root cause of angiogenesis.

Gene, 2022
BACKGROUND AND OBJECTIVE Astrocyte Elevated Gene-1 (AEG-1) is the master and multi-regulator of the various transcriptional factor primarily regulating chemoresistance, angiogenesis, metastasis, and invasion under the pathological condition, including ...
Devan Umapathy, Mano Chitra Karthikeyan, Kumar Ponnuchamy, Mahesh Kumar Kannan, Mathangi Ganesan, Antony Joseph Velanganni Arockiam   +5 more
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LAEG: Leak-based AEG using Dynamic Binary Analysis to Defeat ASLR

International Conference on Data Science in Cyberspace, 2022
Address space layout randomization (ASLR) is a binary protection technique that randomizes a binary's loaded base addresses in every execution. It hardens binaries against exploitation by preventing attackers from reusing identified resources (e.g., code
Wei-Loon Mow, Shih-Kun Huang, H. Hsiao
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p-MEK Expression Predicts Prognosis of Patients with Adenocarcinoma of Esophagogastric Junction (AEG) and Plays a Role in Anti-AEG Efficacy of Huaier.

Pharmacological Research, 2021
The incidence rate of adenocarcinoma of the esophagogastric junction (AEG) is increasing worldwide with poor prognosis and unclear pathogenesis. Trametes robiniophila Murr.
Li Yuan, Shaowei Mo, Zhiyuan Xu, Hang Lv, Jingli Xu, Kaibo Guo, Can Hu, Xiaofeng Wang, Gui-Ping Chen, Jiangjiang Qin, Xiang-dong Cheng   +10 more
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Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH): A Promising Molecular Marker and Therapeutic Target for Hepatocellular Carcinoma

Cancers
Simple Summary Astrocyte elevated gene-1/Metadherin (AEG-1/MTDH) is a gene known for its overexpression in various cancers, including hepatocellular carcinoma (HCC).
Eva Davis, A. G. Ermi, Devanand Sarkar
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AEG-1 Knockdown Sensitizes Glioma Cells to Radiation Through Impairing Homologous Recombination Via Targeting RFC5

DNA and Cell Biology, 2021
Radiotherapy is the most important adjuvant treatment for glioma; however, radioresistance is the major cause for inevitable recurrence and poor survival of glioma patients.
Xu Zhao, Yuchen Sun, Xuanzi Sun, Jing Li, Xiaobo Shi, Zhinan Liang, Yuan Ma, Xiaozhi Zhang   +7 more
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Astrocyte elevated gene-1 (AEG-1) in myeloid cells is a key driver for the development of chemotherapy-induced peripheral neuropathy.

Brain, behavior, and immunity
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of chemotherapy treatment, often resulting in the discontinuation of treatment.
Bryan D. Mckiver, Sarah Herz, Shivani Patel, T. Bryan, Jared Mann, J. Poklis, J. Bigbee, J. Windle, Aliasger K. Salem, Devanand Sarkar, M. Damaj   +10 more
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Sinomenine ameliorates vascular calcification by inhibiting pyroptosis-related molecules and AEG-1 in chronic kidney disease.

European Journal of Pharmacology
BACKGROUND s: Vascular calcification (VC) is an important factor for mortality in chronic kidney disease (CKD). Sinomenine can suppress atherosclerosis. However, its role in CKD-associated-vascular calcification and mechanisms remain unclear.
Zixu Tang, Fengyi Yu, Zhong Peng, Ning Gao, Zihao Liao, Song Zhao, Yuan Xia, Haojun Fu, Shuzhu Zhong, Wei Long, Zhangxiu He   +10 more
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Lymphovascular Invasion (LVI) Correlates with Systemic Immune-Inflammation Index (SII) in Adenocarcinoma of the Gastroesophageal Junction (AEG): Implications for Prognostic Stratification

Cancers
Simple Summary Adenocarcinoma of the gastroesophageal junction (AEG) is an aggressive cancer with poor survival despite curative surgery. Reliable and simple prognostic markers are urgently needed to improve patient management.
G. Jomrich, Winny Yan, Dagmar Kollmann, I. Kristo, B. Fallmann, H. Puhr, A. Ilhan-Mutlu, M. Hollenstein, R. Asari, Christian Sebesta, Sebastian F. Schoppmann   +10 more
semanticscholar   +1 more source

Myeloid AEG-1/MTDH drives inflammation and hepatocellular dysfunction in diet-induced steatohepatitis

Journal of Biological Chemistry
Astrocyte elevated gene-1 (AEG-1)/metadherin plays an important role in regulating lipid metabolism and inflammation in hepatocytes and promotes metabolic dysfunction–associated steatohepatitis (MASH).
Suchismita Raha, Saranya C. Reghupaty, Xufeng Qu, Rachel G. Mendoza, D. Farrar, A. G. Ermi, Eva Davis, Rebecca K. Martin, M. Subler, Paul B. Fisher, J. Windle, Jinze Liu, Devanand Sarkar   +12 more
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