Results 11 to 20 of about 4,539 (66)

Multifunctional Role of Astrocyte Elevated Gene-1 (AEG-1) in Cancer: Focus on Drug Resistance

Cancers, 2021
Simple Summary Chemotherapy is a major mode of treatment for cancers. However, cancer cells adapt to survive in stressful conditions and in many cases, they are inherently resistant to chemotherapy.
Debashri Manna, D. Sarkar
semanticscholar   +1 more source

Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review

Cells, 2021
Tumor breakthrough is driven by genetic or epigenetic variations which assist in initiation, migration, invasion and metastasis of tumors. Astrocyte elevated gene-1 (AEG-1) protein has risen recently as the crucial factor in malignancies and plays a ...
Sushmitha Sriramulu, Xiao-Feng Sun, Sarubala Malayaperumal, H. Ganesan, Hong Zhang, M. Ramachandran, A. Banerjee, S. Pathak   +7 more
semanticscholar   +1 more source

AEG-1 silencing attenuates M2-polarization of glioma-associated microglia/macrophages and sensitizes glioma cells to temozolomide

Scientific Reports, 2021
Glioma is the most frequent primary malignancy in the brain; temozolomide (TMZ) is the first-line chemotherapeutic agent used to combat this tumor. We showed here that astrocyte elevated gene-1 (AEG-1) was overexpressed in glioma tissues and associated ...
Jing Li, Yuchen Sun, Xuanzi Sun, Xu Zhao, Yuan Ma, Yuzhu Wang, Xiaozhi Zhang   +6 more
semanticscholar   +1 more source

LncRNA-ENST00000543604 exerts a tumor-promoting effect via miRNA 564/AEG-1 or ZNF326/EMT and predicts the prognosis of and chemotherapeutic effect in colorectal cancer

Frontiers in Oncology, 2021
Objectives Colorectal cancer(CRC) is a common malignant tumor. Recent studies have found that lncRNAs play an important role in the occurrence and development of colorectal cancer.
Weimin Wang, Zhen Zhou, Xiaojun Dai, Haibo Wang, Jun Jin, Ke Min, Yun-fang Wang, Mengying Lv, Yanqing Liu, Yan Zhou   +9 more
semanticscholar   +1 more source

Pbaeg: combine-vulnerabilities AEG to defeat protection mechanisms

Cybersecurity
Automatic exploit generation (AEG) refers to the process of automatically finding the path in the program that can trigger vulnerabilities and generate exploits.
Yu Wang, Zhoujun Li, Yipeng Zhang
semanticscholar   +1 more source

MicroRNA-1297 inhibits metastasis and epithelial-mesenchymal transition by targeting AEG-1 in cervical cancer

Oncology Report, 2022
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the immunohistochemical data shown in Fig. 4C and the cell migration assay data shown in Fig. 3B and D and Fig. 7B and D were strikingly
Zengyan Wang, Shanyang He, P. Guo, Xu Guo, Jingxuan Zheng   +4 more
semanticscholar   +1 more source

Astrocyte elevated gene-1 (AEG-1): A key driver of hepatocellular carcinoma (HCC)

Advances in Cancer Research, 2021
An array of human cancers, including hepatocellular carcinoma (HCC), overexpress the oncogene Astrocyte elevated gene-1 (AEG-1). It is now firmly established that AEG-1 is a key driver of carcinogenesis, and enhanced expression of AEG-1 is a marker of ...
I. Banerjee, P. Fisher, D. Sarkar
semanticscholar   +1 more source

Spatial transcriptomics unravels palmitoylation and zonation-dependent gene regulation by AEG-1 in mouse liver

Journal of Biological Chemistry
Obesity-induced metabolic dysfunction-associated steatohepatitis (MASH) leads to hepatocellular carcinoma (HCC). Astrocyte-elevated gene-1/Metadherin (AEG-1/MTDH) plays a key role in promoting MASH and HCC.
Alissa Saverino, Xufeng Qu, Rachel G. Mendoza, Suchismita Raha, Debashri Manna, A. G. Ermi, M. Subler, J. Windle, Jinze Liu, Devanand Sarkar   +9 more
semanticscholar   +1 more source

Clinical and prognostic features of MMP-2 and VEGF in AEG patients

Open Medicine, 2021
Adenocarcinoma of the esophagogastric junction (AEG) has been increased in recent years and has become a worldwide problem that seriously affects human health.
Qing-Kang Zheng, Qing Yin, N. Zhang, Zhigang Sun   +3 more
semanticscholar   +1 more source

Effects of environmental concentrations of toxins BMAA and its isomers DAB and AEG on zebrafish larvae.

Ecotoxicology and Environmental Safety
The increasing concern over the environmental presence of β-N-Methylamino-L-alanine (BMAA), a toxin primarily produced by cyanobacteria and diatoms, has stimulated numerous studies to evaluate the risk for exposed populations, mainly aquatic organisms ...
J. Lichtfouse, Audrey Courtier, Annette Vergunst, P. Giannoni   +3 more
semanticscholar   +1 more source