Results 1 to 10 of about 4,539 (66)

Identification of Nucleolin as a Novel AEG-1-Interacting Protein in Breast Cancer via Interactome Profiling

Cancers, 2021
Simple Summary Breast cancer is one of the most common cancers affecting women today. Astrocyte Elevated Gene-1 (AEG-1) is elevated in breast cancer patients and is associated with metastasis and poor prognosis.
Seok-Geun Lee, Jin Young Kim, Young-Ho Chung   +2 more
exaly   +2 more sources

The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A Review

Genes, 2021
Since its initial cloning in 2002, a plethora of studies in a vast number of cancer indications, has strongly established AEG-1 as a bona fide oncogene.
Devanand Sarkar, Sarkar Devanand
exaly   +2 more sources

Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility

Neurobiology of Disease
Astrocyte-elevated gene-1 (AEG-1), also known as metadherin (MTDH) has emerged as a potent oncogene expressed in cancers. An increasing body of evidence indicates AEG-1 plays a pivotal role in various brain pathophysiological processes.
Aifeng Zhang, Feiyu Wang
exaly   +2 more sources

The AEG-1-USP10-PARP1 axis confers radioresistance in esophageal squamous cell carcinoma via facilitating homologous recombination-dependent DNA damage repair.

Cancer Letters, 2023
Radiotherapy is the standard adjuvant treatment for esophageal squamous cell carcinoma (ESCC), yet radioresistance remains a major obstacle leading to treatment failure and unfavorable prognosis.
Xu Zhao, Yuan Ma, Jing Li, Xuanzi Sun, Yuchen Sun, Fengyi Qu, Xiaobo Shi, Yuchen Xie, Siqi Liu, Yanfang Ma, Chao Ji, Weibin Hu, S. Che, Xiaozhi Zhang   +13 more
semanticscholar   +1 more source

Ribosome Biogenesis Regulator 1 Homolog (RRS1) Promotes Cisplatin Resistance by Regulating AEG-1 Abundance in Breast Cancer Cells

Molecules, 2023
Many ribosomal proteins are highly expressed in tumors and are closely related to their diagnosis, prognosis and pathological characteristics. However, few studies are available on the correlation between ribosomal proteins and chemoresistance.
Junying Song, C. Peng, Runze Wang, Yanan Hua, Q. Wu, L. Deng, Yi Cao, Li Zhang, L. Hou   +8 more
semanticscholar   +1 more source

Preoperative BChE serves as a prognostic marker in patients with resectable AEG after neoadjuvant chemotherapy

Langenbeck's archives of surgery (Print), 2023
Background Diminished systemic serum butyrylcholinesterase (BChE), a biomarker for chronic inflammation, cachexia, and advanced tumor stage, has shown to play a prognostic role in various malignancies.
L. Gensthaler, G. Jomrich, J. Brugger, D. Kollmann, M. Paireder, Milena Bologheanu, Alexander Horn, F. M. Riegler, R. Asari, S. Schoppmann   +9 more
semanticscholar   +1 more source

Using the metabolite alterations monitoring the AEG-1 expression level and cell biological behaviour of U251 cell in vitro

PLoS ONE, 2023
Astrocyte elevated gene-1 (AEG-1) is an important oncogene that overexpresses in gliomas and plays a vital role in their occurrence and progression. However, few reports have shown which biomarkers could reflect the level of AEG-1 expression in vivo so ...
Yurui Sheng, Di Yin, Qingshi Zeng
semanticscholar   +1 more source

The palmitoylation of AEG-1 dynamically modulates the progression of hepatocellular carcinoma

Theranostics, 2022
Rationale: Protein palmitoylation is tightly related to tumorigenesis or tumor progression as many oncogenes or tumor suppressors are palmitoylated. AEG-1, an oncogene, is commonly elevated in a variety of human malignancies, including hepatocellular ...
Binhui Zhou, Ying Wang, Lichen Zhang, Xiaoyi Shi, Hesheng Kong, Mengjie Zhang, Yang Liu, Xiazhen Shao, Zhilong Liu, H. Song, Wushan Li, Xiaoxi Gao, Yanli Chang, Chen-Zhuo Dou, Wenzhi Guo, Shuijun Zhang, X. Kang, Jie Gao, Yinming Liang, Junfen Zheng, Eryan Kong   +20 more
semanticscholar   +1 more source

AEG: Argumentative Essay Generation via A Dual-Decoder Model with Content Planning

Conference on Empirical Methods in Natural Language Processing, 2022
Argument generation is an important but challenging task in computational argumentation.Existing studies have mainly focused on generating individual short arguments, while research on generating long and coherent argumentative essays is still under ...
Jianzhu Bao, Yasheng Wang, Yitong Li, Fei Mi, Ruifeng Xu   +4 more
semanticscholar   +1 more source

Transcriptome analysis in an AEG‑1‑deficient neuronal HT22 cell line

Experimental and Therapeutic Medicine, 2022
Astrocyte elevated gene-1 (AEG-1) is a key regulatory factor of progression in multiple types of tumor and neurodegenerative disease development. AEG-1 is associated with glutamate excitotoxicity due to its reported function of repressing excitatory ...
Kunmei Liu, Pan-pan Wan, Yue Huang, Bin Wang, Xuequan Wang, Rui Zhang, Le Guo   +6 more
semanticscholar   +1 more source