Results 1 to 10 of about 21,457 (206)

Effects of dexmedetomidine as an adjuvant to ropivacaine or ropivacaine alone on duration of postoperative analgesia: A systematic review and meta-analysis of randomized controlled trials.

PLoS ONE, 2023
BackgroundRopivacaine is a long-acting local anesthetic that is used to treat postoperative pain. Adjuvant use of dexmedetomidine in regional anesthesia may prolong the duration of analgesia.
Fangzhou Li, Liang Guo, Zijin Huang, Fei Lin, Linghui Pan   +4 more
doaj   +1 more source

Neurotoxicity of a Novel Local Anesthetic Agent, Ropivacaine: The Possible Roles of Bursts of Potential and Cytoplasmic Second Messenger

Journal of the Formosan Medical Association, 2007
Ropivacaine has been shown to induce convulsion following overdose or accidental intravenous injection, but the mechanisms are poorly understood.
Pei-Lin Lin, Shou-Zen Fan, Feng-Fong Tsai, Ming-Cheng Tsai, Chia-Hsien Lin, Chi-Hsiang Huang   +5 more
doaj   +1 more source

Analgesic effect of perineural magnesium sulphate for sciatic nerve block for diabetic toe amputation: A randomized trial. [PDF]

PLoS ONE, 2017
High concentrations of local anesthetics may be neurotoxic for diabetic patients. Additive perineural administration of magnesium was reported to decrease the consumption of local anesthetics for nerve block.
Jiehao Sun, Xiaona Feng, Qihan Zhu, Wendong Lin, Hailei Guo, Emmanuel Ansong, Le Liu   +6 more
doaj   +1 more source

Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study

Revista Brasileira de Anestesiologia, 2015
BACKGROUND AND OBJECTIVES: The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental ...
Angélica de Fátima Braga, Vanessa Henriques Carvalho, Franklin Sarmento Braga, Gloria Maria Braga Potério, Filipe Nadir Caparica Santos   +4 more
doaj   +1 more source

Perbandingan Anestesi Spinal Menggunakan Ropivakain Hiperbarik 13,5 mg dengan Ropivakain Isobarik 13,5 mg terhadap Mula dan Lama Kerja Blokade Sensorik

Jurnal Anestesi Perioperatif, 2014
The spread of the local anesthetic drug in spinal anesthesia is primarily determined by baricity and position. The aim of this study was to compare the onset and duration of sensoric blockade in spinal anaesthesia using 13.5 mg hyperbaric ropivacaine and
Hunter D. Nainggolan, Iwan Fuadi, Ike Sri Redjeki   +2 more
doaj   +1 more source

Effect of caudal ketamine on minimum local anesthetic concentration of ropivacaine in children: a prospective randomized trial

BMC Anesthesiology, 2020
Background Caudal ketamine has been shown to provide an effective and prolonged post-operative analgesia with few adverse effects. However, the effect of caudal ketamine on the minimum local anesthetic concentration (MLAC) of ropivacaine for intra ...
Huai-Zhen Wang, Ling-Yu Wang, Hui-Hong Liang, Yan-Ting Fan, Xing-Rong Song, Ying-Jun She   +5 more
doaj   +1 more source

Ropivacaine inhibits wound healing by suppressing the proliferation and migration of keratinocytes via the PI3K/AKT/mTOR Pathway

BMC Anesthesiology, 2022
Background After surgery, millions of people suffer from delayed healing or wound dehiscence with subsequent severe complications, even death. Previous studies have reported that ropivacaine exhibits anti-proliferative and anti-migratory activities on ...
Xiaoyang Wu, Quanyu Sun, Simeng He, Ya Wu, Shihan Du, Lirong Gong, Jianbo Yu, Haifeng Guo   +7 more
doaj   +1 more source

Comparative study of intrathecal hyperbaric versus isobaric ropivacaine: A randomized control trial

Saudi Journal of Anaesthesia, 2013
Background: Hyperbaric ropivacaine produce more reliable sensory and motor block, with faster onset, better quality of muscles relaxation than isobaric ropivacaine.
Rajni Gupta, Jaishri Bogra, Prithvi Kumar Singh, Sulekha Saxena, Girish Chandra, Jitendra Kumar Kushwaha   +5 more
doaj   +1 more source

Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. [PDF]

PLoS ONE, 2015
Ropivacaine is a local anesthetic widely used for regional anesthesia and epidural analgesia, but its relatively short duration limits its clinical use. A novel sustained release lipid formulation of ropivacaine has been recently developed to prolong its
Teng-Fei Li, Hui Fan, Yong-Xiang Wang
doaj   +1 more source

Ropivacaine Inhibits Lung Cancer Cell Malignancy Through Downregulation of Cellular Signaling Including HIF-1α In Vitro

Frontiers in Pharmacology, 2022
Background: Ropivacaine is widely used to induce regional anesthesia during lung cancer surgery. Previous studies reported that amide-linked local anesthetics, e.g., ropivacaine, affected the biological behavior of lung adenocarcinoma cells, but the ...
Junmei Shen, Lina Han, Yongxian Xue, Chao Li, Huiqun Jia, Kangsheng Zhu   +5 more
doaj   +1 more source