Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]
, 2018 The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique +8 more
core +2 more sources
Severe Postpartum Inguinal Neuralgia Relieved by Ultrasound‐Guided Nerve Blocks: A Case Report
Clinical Case Reports, Volume 14, Issue 3, March 2026.ABSTRACT Postpartum groin pain is common, but neuropathic pain caused by injury to the ilio‐inguinal, iliohypogastric, or genitofemoral nerves is rarely described and may be overlooked. We present the case of a 33‐year‐old breastfeeding woman who developed excruciating left inguinal pain that began shortly before a Pfannenstiel cesarean section and ...
Dan Sebastian Dirzu +1 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 3, March 2026.ABSTRACT Background and Aims Local anesthetic systemic toxicity (LAST) is a rare but potentially life‐threatening complication associated with the use of local anesthetics. Prompt recognition and effective management are critical to preventing severe outcomes. However, studies have shown that healthcare workers' knowledge regarding LAST remains limited,
Vu Tri Thanh +8 more
wiley +1 more source
Journal of Dr. NTR University of Health Sciences, 2016 Background and Aims: Intraperitoneal (IP) instillation of local anesthetics has been shown to minimize postoperative pain after laparoscopic surgeries. We compared the antinociceptive effects of IP dexmedetomidine combined with ropivacaine with that of ...
Sunil Chiruvella, Srinivasa Rao Nallam
doaj +1 more source
Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats [PDF]
, 2017 The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in ...
Beaudry, F +6 more
core +3 more sources
Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
MedComm – Oncology, Volume 5, Issue 1, March 2026.Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source
Six months follow up of a single intravitreal injection of ocriplasmin for symptomatic vitreomacular adhesion [PDF]
, 2016 Purpose: To evaluate the efficacy and the safety of the enzymatic vitreolysis with a single intravitreal injection of ocriplasmin 125 μg across a group of patients with symptomatic vitreomacular adhesion (sVMA) during 6 months follow up.
GUZZO, Anna Santa +6 more
core +2 more sources
Pregnancy, Volume 2, Issue 2, March 2026.Abstract Objective To evaluate the effect on maternal pain of local anesthetic wound infiltration for intra‐cesarean delivery analgesia in patients who also received intrathecal opioids Data sources Scopus, PubMed, and Cochrane Central Register of Controlled Trials were searched from the inception of each database to August 2023.
Valentina Frusone +8 more
wiley +1 more source
Efeitos de Anestésico Local no Tempo Entre Bólus e na Duração do Trabalho de Parto em Patient-Controlled Epidural Analgesia: Estudo Prospectivo de Dois Regimes de Doses Ultra-Baixas com Ropivacaina e Sufentanil [PDF]
, 2015 BACKGROUND: Patient-controlled epidural analgesia with low concentrations of anesthetics is effective in reducing labor pain. The aim of this study was to assess and compare two ultra-low dose regimens of ropivacaine and sufentanil (0.1% ropivacaine plus
Costa Martins, JM +3 more
core
Comparing continuous lumbar plexus block, continuous epidural block and continuous lumbar plexus block with a parasacral sciatic nerve block on post-operative analgesia after hip arthroplasty [PDF]
, 2011 Study Objective: To compare post-operative analgesia obtained by continuous lumbar epidural block (CLEB) versus continuous lumbar plexus block (CLPB) versus CLPB associated with a single shot parasacral sciatic nerve block (CLEBS) after total hip ...
Celidonio, L +6 more
core +1 more source