Results 201 to 210 of about 22,496 (211)

Steroid receptor coactivators in immunity - From function to emerging translational opportunities. [PDF]

J Biol Chem
Gilad Y, Lonard DM.
europepmc   +1 more source

Compositional maturation of the microbiome and adaptive immunity in the postnatal period. [PDF]

Front Immunol
Green M, Cleary S, Kwiecien-Delaney B, Foster JA.   +3 more
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Intervention with Polyvalent Bacterial Lysate Modulates T Helper Cell Subsets in Polish Children with Grass Pollen-Induced Allergic Rhinitis. [PDF]

Biomedicines
Janeczek K, Grzegorzewska W, Zarobkiewicz M, Suszczyk D, Mikołajczyk M, Markut-Miotła E, Morawska-Michalska I, Bakiera A, Chmielewska A, Emeryk A, Roliński J, Rachel M, Piotrowska-Weryszko K.   +12 more
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Malathion-induced neurological alterations associated with dysregulation of RORγt/STAT3/IL-17 and FOXP3/STAT5/IL-10 pathways: potential neuroprotective effects of BCG. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Aborehab NM, Abd-Elmawla MA, Aboulmagd YM, El-Mahdy SM, Shahine YM, Osman EM, Magdoub HME.   +6 more
europepmc   +1 more source

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1-Oleoyl-lysophosphatidylethanolamine stimulates RORγt activity in TH17 cells

Science immunology, 2023
Metabolic fluxes involving fatty acid biosynthesis play essential roles in controlling the differentiation of T helper 17 (TH17) cells. However, the exact enzymes and lipid metabolites involved, as well as their link to promoting the core gene ...
Yusuke Endo, T. Kanno, T. Nakajima, Kazutaka Ikeda, Y. Taketomi, Satoru Yokoyama, S. Sasamoto, Hikari K. Asou, Keisuke Miyako, Y. Hasegawa, Y. Kawashima, O. Ohara, M. Murakami, T. Nakayama   +13 more
semanticscholar   +1 more source

The CCR6/CCL20 Axis Expands RORγt+ Tregs to Protect from Glomerulonephritis.

Kidney International, 2023
Previous studies have identified a unique Treg population, which expresses the Th17 characteristic transcription factor RORγt. These RORγt+ Tregs possess enhanced immunosuppressive capacity, which endows them with great therapeutic potential. However, as
G. Herrnstadt, C. B. Niehus, T. Ramcke, J. Hagenstein, L. Ehnold, Anna Nosko, M. Warkotsch, F. C. Feindt, Simon Melderis, H. Paust, Varshi Sivayoganathan, S. Jauch-Speer, M. N. Wong, D. Indenbirken, C. Krebs, T. Huber, U. Panzer, Victor G. Puelles, M. Kluger, O. Steinmetz   +19 more
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Synthesis and identification of lithocholic acid 3‐sulfate as RORγt ligand to inhibit Th17 cell differentiation

Journal of Leukocyte Biology, 2022
Primary bile acids (BAs), products of cholesterol metabolism and clearance, are synthesized in the liver and released into the intestine to facilitate the digestion and absorption of lipids.
Riping Xiao, Kawai Lei, Hioha Kuok, Wen-De Deng, Yu-Xin Zhuang, Yan Tang, Zhengyang Guo, Hong-Yan Qin, Li-Ping Bai, Ting Li   +9 more
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Retinoic acid-related orphan receptor gamma t (RORγt) inverse agonists/antagonists for the treatment of inflammatory diseases – where are we presently?

Expert Opinion on Drug Discovery, 2021
Introduction: The transcription factor retinoic acid-related orphan receptor gamma t (RORγt) has been identified as the master regulator of TH17 cell differentiation and IL-17/22 production and is therefore an attractive target for the treatment of ...
C. Gege
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Core fucosylation of maternal milk N-glycans imparts early-life immune tolerance through gut microbiota-dependent regulation in RORγt+ Treg cells.

Food & Function
Milk glycans play key roles in shaping and maintaining a healthy infant gut microbiota. Core fucosylation catalyzed by fucosyltransferase (Fut8) is the major glycosylation pattern on human milk N-glycan, which was crucial for promoting the colonization ...
Yu-Yuan Li, Xixi Ning, Zihui Zhao, Xi He, Qi-Di Xue, Manlin Zhou, Wen-Zhe Li, Ming Li   +7 more
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