Results 291 to 300 of about 24,235,259 (324)

Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.

, 2019
Starting from a previously reported RORγ inhibitor (1), successive efforts to improve in vivo potency were continued. Introduction of metabolically beneficial motifs in conjunction with scaffold hopping was examined, resulting in discovery of the second ...
M. Kotoku, Takaki Maeba, Fujioka Shingo, Yokota Masahiro, Seki Noriyoshi, Keisuke Ito, Yoshihiro Suwa, Taku Ikenogami, Kazuyuki Hirata, Y. Hase, Yoshiaki Katsuda, Naoki Miyagawa, Kojo Arita, Kota Asahina, M. Noguchi, A. Nomura, S. Doi, T. Adachi, P. Crowe, Haiyan Tao, S. Thacher, Hiromasa Hashimoto, Takayoshi Suzuki, Makoto Shiozaki   +23 more
semanticscholar   +1 more source

Can melatonin regulate the expression of prohormone convertase 1 and 2 genes via monomeric and dimeric forms of RZR/ROR nuclear receptor, and can melatonin influence the processes of embryogenesis or carcinogenesis by disturbing the proportion of cAMP and cGMP concentrations? Theoretic model of controlled apoptosis

Medical Hypotheses, 2001
The presented model of controlled apoptosis has been based on the assumption that correct information exchange between an organism as a whole, and each of its cells is conditioned by mutual proportions of cAMP and cGMP concentrations (CcAMP, CcGMP), according to the formula CcAMP x CcGMP = 'a' (constant).
openaire   +2 more sources

Computational model predicts patient outcomes in Luminal B breast cancer treated with endocrine therapy and CDK4/6 inhibition.

Clinical Cancer Research
PURPOSE Development of a computational biomarker to predict, prior to treatment, the response to CDK4/6 inhibition (CDK4/6i) in combination with endocrine therapy in patients with breast cancer. EXPERIMENTAL DESIGN A mechanistic mathematical model that
Leonard Schmiester, F. Brasó-Maristany, B. González-Farré, T. Pascual, J. Gavilá, Xavier Tekpli, Jürgen Geisler, V. Kristensen, A. Frigessi, A. Prat, A. Köhn-Luque   +10 more
semanticscholar   +1 more source

P1‐230: Personalized Predictive Modeling ror Alzheimer’s Disease Patients

Alzheimer's & Dementia, 2016
Eric Stallard, Yaakov Stern
openaire   +1 more source

The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries

Immunity, 2023
Silvia Galván-Peña, Ricardo N Ramirez, Andres R Muñoz-Rojas   +2 more
exaly  

746P Synergistic antitumor efficacy of INV-71 ROR gamma agonist with immune checkpoint inhibitor anti-PD-1 in a murine orthotopic 4T1 breast cancer model

Annals of Oncology, 2022
C. Sebesta, V. Chung, A.B. El-Khoueiry, J. Tilley, W. Windsor, T. Stouch, J. Ellingboe, C. Zhang, A. Gaweco   +8 more
openaire   +1 more source

RORγt protein modifications and IL-17-mediated inflammation

Trends in Immunology, 2021
Ritesh Kumar, Arianne L Theiss, K Venuprasad   +2 more
exaly  

The lncRNA ROR/miR-124-3p/TRAF6 axis regulated the ischaemia reperfusion injury-induced inflammatory response in human cardiac myocytes

Journal of Bioenergetics and Biomembranes, 2019
Ying-Ping Liang, Qin Liu, Guo-hai Xu, Jing Zhang, Yong Chen, Fu-zhou Hua, Changqing Deng, Yanhui Hu   +7 more
semanticscholar   +1 more source

Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases

Journal of Pharmaceutical Analysis, 2023
Qianyun Zhao, Shulin Wei
exaly  

Involvement of Microbiome Gut–Brain Axis in Neuroprotective Effect of Quercetin in Mouse Model of Repeated Mild Traumatic Brain Injury

Neuromolecular medicine, 2022
Ramya Balasubramanian, Mohd Rabi Bazaz, Tulasi Pasam, Naserunnisa Sharief, Laximan Velip, Gananadhamu Samanthula, Manoj P. Dandekar   +6 more
semanticscholar   +1 more source