Results 41 to 50 of about 24,235,259 (324)
CD4+RORγt++ and Tregs in a Mouse Model of Diet‐Induced Nonalcoholic Steatohepatitis [PDF]
Mediators of Inflammation, 2015 Background and Aims. Inflammatory mediators that cross‐talk in different metabolically active organs are thought to play a crucial role in the pathogenesis of Nonalcoholic Steatohepatitis (NASH). This study was aimed at investigating the CD4+RORγt+ T‐helper cells and their counterpart, the CD4+CD25+FOXP3+ regulatory T cells in the liver, subcutaneous ...
Luisa Vonghia +11 more
openaire +3 more sources
Development and testing of a polygenic risk score for breast cancer aggressiveness
npj Precision Oncology, 2023 Aggressive breast cancers portend a poor prognosis, but current polygenic risk scores (PRSs) for breast cancer do not reliably predict aggressive cancers. Aggressiveness can be effectively recapitulated using tumor gene expression profiling.
Yiwey Shieh +22 more
doaj +1 more source
The effects of run-of-river hydroelectric power schemes on invertebrate community composition in temperate streams and rivers. [PDF]
PLoS ONE, 2017 Run-of-river (ROR) hydroelectric power (HEP) schemes are often presumed to be less ecologically damaging than large-scale storage HEP schemes. However, there is currently limited scientific evidence on their ecological impact.
Gary S Bilotta +4 more
doaj +1 more source
Archetype Model-Driven Development Framework for EHR Web System [PDF]
Healthcare Informatics Research, 2013 ObjectivesThis article describes the Web application framework for Electronic Health Records (EHRs) we have developed to reduce construction costs for EHR sytems.MethodsThe openEHR project has developed clinical model driven architecture for future-proof
Shinji Kobayashi +2 more
doaj +1 more source
Clinical Pathology, 2023 Aims: To assess the impact of the molecular subtype (MS) on the total number of CK19 mRNA copies in all positive SLN (TTL) threshold, to predict non-SLN affectation, and to compare 5 years progression-free survival (PFS) according to the risk of ...
L Bernet +9 more
doaj +1 more source
Journal of Engineering and Applied Sciences Technology, 2021 The specialists estimate that the most important challenge on the beaches is the dumping of sand. Sustainable tourism in our time must be conceived towards the future to ensure that resources are managed with due protection of ecological processes, biological diversity and the environment in general, hence our objective is to ...
Ricardo Oses Rodriguez +1 more
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FRI0153 Role of ror gamma t inhibition in the il-23 minicircle model and spa patient tissue cultures [PDF]
Annals of the Rheumatic Diseases, 2018 Background Retinoic acid receptor related Orphan Receptor gamma t (RORγt) is a nuclear hormone receptor expressed in a subset of pathogenic T cells and innate lymphoid cells. RORγt regulates the transcription of key pro inflammatory cytokines such as IL-17 and IL-22 in response to multiple activation signals including cytokines and T cell receptor ...
K. Hoyt +10 more
openaire +1 more source
WNT5a-ROR Signaling Is Essential for Alveologenesis
Cells, 2020 WNT5a is a mainly “non-canonical” WNT ligand whose dysregulation is observed in lung diseases such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and asthma.
Changgong Li +11 more
semanticscholar +1 more source
Journal of Thoracic Disease, 2021 Background Long non-coding RNAs (lncRNAs) are a class of non-protein coding RNAs greater than 200 nucleotides (nt) in length which have been shown to be significantly highly expressed in the heart tissue of mice undergoing thoracic aortic arch ...
Ya Yang +5 more
semanticscholar +1 more source
Ecosphere, 2021 Predicting whether anthropogenic sources of mortality have negative consequences at the level of population dynamics is challenged by mechanisms like density‐dependent survival that can amplify or offset the loss of individuals from anthropogenic ...
Pascale Gibeau, Wendy J. Palen
doaj +1 more source