Results 71 to 80 of about 24,235,259 (324)

Functional characterization of anti-CD19 CAR-T lymphocytes polarized for the Th17 phenotype through RORγt overexpression

, 2022
A transferência adotiva de linfócitos T modificados para expressar receptores de antígeno quiméricos (CAR) anti-CD19 tem resultado em taxas de remissão completa superiores a 80% em pacientes com leucemia linfoblástica aguda de células B.
Brand, Heloisa
core   +1 more source

Incorporation of Selenium into Sol–Gel‐Derived Bioactive Glass: Influence on Glass Structure, Bioactivity, and its Selective Cytotoxicity

Advanced Engineering Materials, EarlyView.
Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni, Thalita Marcolan Valverde, Talita Martins, Guilherme Mattos Jardim Costa, Alfredo Miranda de Goes, Marcello Rosa Dumont, Eduardo Henrique Martins Nunes, Marivalda de Magalhães Pereira   +7 more
wiley   +1 more source

A Micro-Foundational Model of Real Options Reasoning:The Roles of Individual Search Propensity and Perceived Uncertainty

, 2021
Research Summary: To explain heterogeneity in real options reasoning (ROR) across entrepreneurial ventures, we propose a microfoundational model to explore the relationships between a firm leader's search propensity, perceived uncertainty and the firm ...
Gao, Renfei, Leatherbee Grant, Michael Gerald, Zhang, X., Odeh, Nicolas, Zhang, Stephen X., Stephen X. Zhang, Gao, R., Renfei Gao, Michael Leatherbee, Odeh Yarad, Nicolás Esteban, Gao, Renfei; id_orcid, Leatherbee, M., Zhang, Stephen, Leatherbee, Michael, Nicolás Odeh, Odeh, N.   +15 more
core   +1 more source

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

Advanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares, Nadège Bouchonneau, Christian Jochum, Donald Radford   +3 more
wiley   +1 more source

DNA Damage-Induced ROR alpha Is Crucial for p53 Stabilization and Increased Apoptosis

, 2018
A critical component of the DNA damage response is the p53 tumor suppressor, and aberrant p53 function leads to uncontrolled cell proliferation and malignancy.
Bhin, J, Lee, G, Pyo, KE, Yim, HY, Kim, H, Lee, JM, Baek, SH, Chung, J, Hwang, D, Oh, SK, Il Kim, K, Kim, K, Lee, JS   +12 more
core   +1 more source

Cathodic Cage Plasma Deposition of Nanostructured Cu–Fe–Se Coatings on Poly(methyl Methacrylate)

Advanced Engineering Materials, EarlyView.
Nanostructured Cu–Fe–Se coatings are deposited on PMMA by a modified cathodic cage plasma process, enabling low‐temperature deposition on polymer substrates. A transition from discontinuous to compact morphology is observed with temperature, with optimal properties at 200°C, where improved CuFeSe2‐type bonding, lowest sheet resistance, and favorable ...
V. S. S. Sobrinho, M. Naeem, T. H. C. Costa, M. S. Libório, J. C. A. Queiroz, C. B. B. Luna, R. R. M. Sousa, P. S. Vieira, E. M. Araújo   +8 more
wiley   +1 more source

Grain Refinement During Severe Plastic Deformation and Similitude of Subgrain Formation: A Molecular Dynamics Study

Advanced Engineering Materials, EarlyView.
Molecular dynamics is used to investigate structure refinement during severe plastic deformation. The results show similitude with experimental data. Molecular dynamics simulations of severe plastic deformation of monocrystalline and polycrystalline samples by multiaxial compression of aluminum are carried out.
Roberto B. Figueiredo
wiley   +1 more source

APOE-ε4 allele[s]-associated adverse events reported from placebo arm in clinical trials for Alzheimer's disease: implications for anti-amyloid beta therapy

Frontiers in Dementia
APOE-ε4 allele[s] is a risk factor for Alzheimer's disease (AD) and Amyloid-Related Imaging Abnormalities (ARIA) in anti-amyloid beta therapy, and is also associated with cerebrovascular risk factors such as hyperlipidemia or atherosclerosis.
Kenichiro Sato, Kenichiro Sato, Yoshiki Niimi, Ryoko Ihara, Kazushi Suzuki, Atsushi Iwata, Takeshi Iwatsubo, Takeshi Iwatsubo   +7 more
doaj   +1 more source

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

Coupling of Er3+ ions and Plasmonic Modes in Vertical Nanocavities for Spectral Broadening in Telecom Bands

Advanced Materials Technologies, EarlyView.
Left: Illustration of the glass & nanostructures system and the NIR emission at 1.5 µm, where the colored spheres represent the Er3+ ions within the doped glass. Right: Representation of the Stark splitting of the 4I13/2 and 4I15/2 manifolds of the Er3+, illustrating how the plasmonic modes facilitate the emission from the broader Stark manifold ...
Gaston Lozano Calderón, Víctor Anthony García Rivera, Stéphan Cagnon, Souleymane Toubou Bah, Younès Messaddeq, Euclydes Marega Junior   +5 more
wiley   +1 more source