Results 11 to 20 of about 38,562 (318)

TLR7 promotes skin inflammation via activating NFκB-mTORC1 axis in rosacea [PDF]

PeerJ, 2023
Rosacea is a chronic inflammatory skin disease originated from damaged skin barrier and innate/adaptive immune dysregulation. Toll-like receptors (TLRs) sense injured skin and initiate downstream inflammatory and immune responses, whose role in rosacea ...
Yaqun Huang, Da Liu, Mengting Chen, San Xu, Qinqin Peng, Yan Zhu, Juan Long, Tangxiele Liu, Zhili Deng, Hongfu Xie, Ji Li, Fangfen Liu, Wenqin Xiao   +12 more
doaj   +3 more sources

A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea

EMBO Molecular Medicine, 2021
Rosacea is a chronic inflammatory skin disorder whose pathogenesis is unclear. Here, several lines of evidence were provided to demonstrate that mTORC1 signaling is hyperactivated in the skin, especially in the epidermis, of both rosacea patients and a ...
Zhili Deng, Mengting Chen, Yingzi Liu, San Xu, Yuyan Ouyang, Wei Shi, Dan Jian, Ben Wang, Fangfen Liu, Jinmao Li, Qian Shi, Qinqin Peng, Ke Sha, Wenqin Xiao, Tangxiele Liu, Yiya Zhang, Hongbing Zhang, Qian Wang, Lunquan Sun, Hongfu Xie, Ji Li   +20 more
doaj   +2 more sources

Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea

Frontiers in Immunology, 2021
Rosacea is significantly associated with dementia, particularly Alzheimer’s disease (AD). However, the common underlying molecular mechanism connecting these two diseases remains limited.
Huaxiong Zhang, Huaxiong Zhang, Huaxiong Zhang, Yiya Zhang, Yiya Zhang, Yiya Zhang, Yangfan Li, Yangfan Li, Yaling Wang, Yaling Wang, Sha Yan, Sha Yan, San Xu, San Xu, San Xu, Zhili Deng, Zhili Deng, Zhili Deng, Xinling Yang, Hongfu Xie, Hongfu Xie, Hongfu Xie, Ji Li, Ji Li, Ji Li, Ji Li   +25 more
doaj   +2 more sources

Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea

Nature Communications
Rosacea is a chronic inflammatory skin disorder, whose underlying cellular and molecular mechanisms remain obscure. Here, we generate a single-cell atlas of facial skin from female rosacea patients and healthy individuals.
Mengting Chen, Li Yang, Peijie Zhou, Suoqin Jin, Zheng Wu, Zixin Tan, Wenqin Xiao, San Xu, Yan Zhu, Mei Wang, Dan Jian, Fangfen Liu, Yan Tang, Zhixiang Zhao, Yingxue Huang, Wei Shi, Hongfu Xie, Qing Nie, Ben Wang, Zhili Deng, Ji Li   +20 more
doaj   +2 more sources

High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating γδ T cells directly

Nature Communications
Rosacea patients show facial hypersensitivity to stimulus factors (such as heat and capsaicin); however, the underlying mechanism of this hyperresponsiveness remains poorly defined.
Yiya Zhang, Tao Li, Han Zhao, Xin Xiao, Ximin Hu, Ben Wang, Yingxue Huang, Zhinan Yin, Yun Zhong, Yangfan Li, Ji Li   +10 more
doaj   +2 more sources

Multi-Transcriptomic Analysis and Experimental Validation Implicate a Central Role of STAT3 in Skin Barrier Dysfunction Induced Aggravation of Rosacea

Journal of Inflammation Research, 2022
Yaling Wang,1,2 Ben Wang,1,2 Yingxue Huang,1 Yangfan Li,1,2 Sha Yan,1 Hongfu Xie,1– 3 Yiya Zhang,1– 3 Ji Li1– 3 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Hunan Key Laboratory of Aging ...
Wang Y, Wang B, Huang Y, Li Y, Yan S, Xie H, Zhang Y, Li J   +7 more
doaj   +2 more sources

Risk Factor Analysis Based on Disease Severity: Rosacea Disease Management Strategies and Personalized Recommendations. [PDF]

J Cosmet Dermatol
ABSTRACT Background Rosacea is a common chronic inflammatory skin disease with complex causes and varied clinical manifestations. While risk factors for its onset have been studied, key factors associated with disease severity remain unclear. Identifying these factors is essential for optimizing management and treatment strategies. Aims This study aims
Liu H, Zhang L, Yuan J, Liang J, Zhang Y, Gao Z, Chen Y, Wang Y, Li Y, Zeng W, Yang F.   +10 more
europepmc   +2 more sources

Rosacea: New Concepts in Classification and Treatment

American Journal of Clinical Dermatology, 2021
Rosacea is a chronic inflammatory dermatosis mainly affecting the cheeks, nose, chin, and forehead. Rosacea is characterized by recurrent episodes of flushing or transient erythema, persistent erythema, phymatous changes, papules, pustules, and ...
E. V. van Zuuren, B. Arents, M. M. D. van der Linden, Sofieke Vermeulen, Z. Fedorowicz, Jerry Tan   +5 more
semanticscholar   +1 more source

Assessment of thyroid disorders in patients with rosacea: a large case-control study,

Anais Brasileiros de Dermatologia, 2021
Background: The frequency of autoimmune diseases and thyroid cancer has been increasingly reported in association with rosacea. However, studies investigating thyroid diseases in rosacea are scarce with conflicting results. Objective: To investigate the
Asli Akin Belli, Emine Tugba Alatas, Asude Kara Polat, Gulhan Akbaba   +3 more
doaj   +1 more source

Laser and energy-based devices for treating rosacea - a systematic review and network meta-analysis. [PDF]

J Dtsch Dermatol Ges
Summary Background and Objectives Rosacea is a chronic inflammatory condition affecting the central face. While laser and energy‐based devices (EBDs) are commonly used for managing vascular symptoms, comprehensive comparisons between systems are limited.
Nguyen L, Sorbe C, Seeber N, Schneider SW, Herberger K.   +4 more
europepmc   +2 more sources