Results 121 to 130 of about 16,425 (239)
ABSTRACT Accurate modeling of the structures of protein–protein complexes and other biomolecular interactions represents a longstanding and important challenge for computational biology. The Critical Assessment of PRedicted Interactions (CAPRI) experiment has served for over two decades as a key means to assess and compare current approaches and ...
Ragul Gowthaman +4 more
wiley +1 more source
Abstract Cyclic peptides with backbone N-methylated amino acids (BNMeAAs) and D-amino acids (D-AAs) have gained increasing attention for their stability, membrane permeability, and other therapeutic potentials.
Zhigang Cao +6 more
doaj +1 more source
Pioneer personal history questionnaire, Rosetta A. Pearson Stark
Transcript of answers by Rosetta (Pearson) Stark for a questionnaire filled out for Utah Works Progress Administration\u27s "Pioneer personal history" survey, Born in California, she married James Stark of Circleville in 1877. Typed by Walter J. Cropper
Stark, Rosetta Pearson, 1858-
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ABSTRACT Artificial protein design enables the creation of stable scaffolds beyond those evolved in nature. Incorporation of native functional motifs into de novo scaffolds provides a promising strategy to mimic natural interactions while altering structural frameworks.
Hakuto Miyoshi +7 more
wiley +1 more source
Oppositely Charged Homopolypeptides Form Ordered Helix Assemblies With Hierarchical Structure
Hexagaonal and square assembly of polyarginine alfa‐helices formed in highly ordered polyarginine/polyaspartic acid complexes. The helices exhibit additional periodic staggering along their helical axis. ABSTRACT Oppositely charged polyelectrolytes are known to form polyelectrolyte complexes.
Ekaterina Buvalaia +10 more
wiley +1 more source
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin +10 more
wiley +1 more source
Vol. XXIV, Tab 61 - Ex. 2 - Rosetta Stone\u27s Answers to Google\u27s First Set of Interrogatories [PDF]
Exhibits from the un-sealed joint appendix for Rosetta Stone Ltd., v. Google Inc., No. 10-2007, on appeal to the 4th Circuit. Issue presented: Under the Lanham Act, does the use of trademarked terms in keyword advertising result in infringement when ...
Rosetta Stone
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Gough's Cave is a key archaeological site that has been at heart of British archaeology for the past century. Professor Chris Stringer, whom this special issue honours, has been a key figure in excavations and research projects at the site for many decades.
William A. Marsh
wiley +1 more source
Small glitches, but Rosetta comet mission is achieving major scientific goals [PDF]
First paragraph: The landing of Rosetta’s Philae on comet 67P/Churyumov–Gerasimenko was a triumph of engineering. Many spectacular scientific firsts will follow now, but small glitches during the landing make it more difficult to obtain all ...
Schröder, Christian
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