Results 51 to 60 of about 45,576 (293)

A Rosetta Stone for Understanding Infectious Drops and Aerosols.

Journal of the Pediatric Infectious Diseases Society, 2020
The coronavirus disease 2019 (COVID19) pandemic confronts the medical and public health professions with the difficult task of controlling the first and maybe the second waves of infection with limited antiviral medications and without vaccines.
D. Milton
semanticscholar   +1 more source

The Thermal, Mechanical, Structural, and Dielectric Properties of Cometary Nuclei After Rosetta [PDF]

Space Science Reviews, 2019
The physical properties of cometary nuclei observed today relate to their complex history and help to constrain their formation and evolution. In this article, we review some of the main physical properties of cometary nuclei and focus in particular on ...
O. Groussin, N. Attree, N. Attree, Y. Brouet, V. Ciarletti, B. Davidsson, G. Filacchione, H. Fischer, B. Gundlach, M. Knapmeyer, J. Knollenberg, R. Kokotanekova, R. Kokotanekova, R. Kokotanekova, E. Kührt, C. Leyrat, David W. Marshall, David W. Marshall, I. Pelivan, Y. Skorov, Y. Skorov, C. Snodgrass, C. Snodgrass, T. Spohn, F. Tosi   +24 more
semanticscholar   +1 more source

A novel gene conserved from yeast to humans is involved in sterol biosynthesis

Journal of Lipid Research, 2001
The ERG28 gene was originally identified by microarray expression profiling as possibly involved in the Saccharomyces cerevisiae sterol pathway. Microarray analyses suggested that the transcription pattern of ERG28 closely followed that of genes involved
D. Gachotte, J. Eckstein, R. Barbuch, T. Hughes, C. Roberts, M. Bard   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The organization of the Rosetta grammars [PDF]

Proceedings of the fourth conference on European chapter of the Association for Computational Linguistics -, 1989
In this paper the organization of the grammars in the Rosetta machine translation system is described and it is shown how this organization makes it possible to translate between words of different syntactic categories in a systematic way. It is also shown how the organization chosen makes it possible to translate 'small clauses' into full clauses and ...
openaire   +2 more sources

Combining Rosetta Sequence Design with Protein Language Model Predictions Using Evolutionary Scale Modeling (ESM) as Restraint

ACS Synthetic Biology
Computational protein sequence design has the ambitious goal of modifying existing or creating new proteins; however, designing stable and functional proteins is challenging without predictability of protein dynamics and allostery.
M. Ertelt, Jens Meiler, Clara T. Schoeder   +2 more
semanticscholar   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Redirecting a Native Ene‐Reductase Toward Desaturation With Reverse Enantioselectivity

Angewandte Chemie, EarlyView.
A native ene‐reductase, XenA, was repurposed to catalyze the reverse‐enantioselective desaturation of cyclohexanones. The final variant was obtained through extensive protein engineering, combining PROSS‐guided computational design with mutagenesis and screening.
Qing‐Qing Zeng, Cristina Berga, Carla Calvó‐Tusell, Marc Garcia‐Borràs, Zhen Liu   +4 more
wiley   +2 more sources

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Accuracy of Different Methods in Determination of the Van Genuchten,s Retention Curve Coefficients [PDF]

مهندسی منابع آب, 2015
Soil water retention curve is an indicator of one of the most important soil hydrological properties that have high applications in various soil water issues, and it is widely estimated by the van Genuchten,s model.
H. Bagheri, H. ZareAbyaneh, P. Afrasiyab, A. Afrozi   +3 more
doaj