Results 61 to 70 of about 16,425 (239)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

مقارنة ثلاث طرائق مختلفة من أجل قياس التوصيل الهيدروليكي المشبع للتربة

مجلة جامعة دمشق للعلوم الزراعية, 2021
اُستخدمت في هذا البحث ثلاث طرائق مختلفة من أجل قياس التوصيل الهيدروليكي المشبع للتربة (ks)، تشمل طريقة الضاغط المائي الثابت، طريقة المحاكاة باستخدام البرنامج Rosetta وطريقة Wind.
إياد سراي الدين
doaj  

MONITORING OF AMMONIA IN ROSETTA BRANCH

Journal of Environmental Science, 2016
Rosetta branch is a source of fresh water for domestic, agriculture, industry, fisheries and recreation purposes for some western Delta governorates in Egypt. Unfortunately this branch is impacted by increasing concentrations of ammonia resulted from the
Abdullah, N. A, Abd El-Razek, T. M. A, Abdelmawla, M. A.   +2 more
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Advanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Vol. IX, Tab 41 - Ex. 28 - Rosetta Stone Unjust Enrichment Calculations [PDF]

, 2010
Exhibits from the un-sealed joint appendix for Rosetta Stone Ltd., v. Google Inc., No. 10-2007, on appeal to the 4th Circuit. Issue presented: Under the Lanham Act, does the use of trademarked terms in keyword advertising result in infringement when ...
Rosetta Stone
core   +1 more source

De Novo Design and Structural Optimization of Mn(salen)‐Based Artificial Metalloenzymes for Asymmetric Sulfoxidation

Angewandte Chemie, EarlyView.
We report the computational design of de novo proteins that bind Mn(salen)‐based complexes (L1) using Rosetta FastDesign and verified by AlphaFold2. After screening, the catalytic activity for the promising design (dnMSBP) toward enantioselective sulfoxidation of thioanisole was optimized based on its crystal structure. With 10 different substrates, we
Jing‐Xiang Wang, Yunling Deng, Indrek Kalvet, Amira Haque, Huiguang Dai, David Baker, Yi Lu   +6 more
wiley   +2 more sources

Vol. IX, Tab 47 - Ex. 2-9 - Documents Rosetta Stone Competitive WebSite Analytics Report [PDF]

, 2009
Exhibits from the un-sealed joint appendix for Rosetta Stone Ltd., v. Google Inc., No. 10-2007, on appeal to the 4th Circuit. Issue presented: Under the Lanham Act, does the use of trademarked terms in keyword advertising result in infringement when ...
Rosetta Stone
core   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Vol. IX, Tab 47 - Ex. 10 - Document Rosetta Stone Affiliate Overview - Nov. 29, 2007 [PDF]

, 2007
Exhibits from the un-sealed joint appendix for Rosetta Stone Ltd., v. Google Inc., No. 10-2007, on appeal to the 4th Circuit. Issue presented: Under the Lanham Act, does the use of trademarked terms in keyword advertising result in infringement when ...
Rosetta Stone
core   +1 more source