Results 61 to 70 of about 90,351 (277)

The representation of conflict in the discourse of Italian melodrama [PDF]

, 2006
This paper is part of an extensive study of cinematic dialogue in a variety of film genres in Italian, which aims to address the disregard for the verbal plane that characterises film theory and, particularly, genre theory.
Amelio, Blum-Kulka, Blum-Kulka, Brenneis, Camras, Clayman, Eggins, Fele, Giordana, Goffman, Goodwin, Goodwin, Greatbatch, Grice, Halliday, Halliday, Halliday, Herman, Hutchby, Jackson, Jacobs, Kakava, Kakava, Katriel, Kochman, Kotthoff, Kozloff, Krainer, Labov, Lein, Marcondes de Souza Filho, Maynard, McConnell, McLaughlin, Neale, Noguchi, Pomerantz, Pratt, Reinhart, Roberta Piazza, Roffman, Rossi, Sacks, Schegloff, Schiffrin, Small, Sperber, Stein, Tannen, Van Eemeren, Vuchinich, Walton, Walton, Wees   +53 more
core   +1 more source

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

Advanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao, Qianwen Lyu, Tinghao Zhang, Yupan Zou, Yue Xie, Dandan Yang, Cao Xu, Xiaozhen Huang   +7 more
wiley   +1 more source

شبیه‌سازی پروفیل رطوبتی خاک در سیستم آبیاری قطره‌ای سطحی و زیرسطحی با استفاده از مدل HYDRUS-2D [PDF]

پژوهش‌های حفاظت آب و خاک, 2016
سیستم آبیاری قطره‌ای یکی از موثرترین راهکارها برای افزایش بهره‌وری و استفاده بهینه از منابع آب موجود می‌باشد. درک توانایی‌های کامل روش‌های آبیاری قطره‌ای نیازمند بهینه‌سازی پارامترهای در دسترس می‌باشد. مهمترین این پارامترها شامل دور، شدت و زمان آبیاری می‌
سینا بشارت, سودابه ملایی توانی   +1 more
doaj   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

δ‐Conotoxin Structure Prediction and Analysis through Large‐Scale Comparative and Deep Learning Modeling Approaches

Advanced Science
The δ‐conotoxins, a class of peptides produced in the venom of cone snails, are of interest due to their ability to inhibit the inactivation of voltage‐gated sodium channels causing paralysis and other neurological responses, but difficulties in their ...
Stephen McCarthy, Shane Gonen
doaj   +1 more source

مقارنة ثلاث طرائق مختلفة من أجل قياس التوصيل الهيدروليكي المشبع للتربة

مجلة جامعة دمشق للعلوم الزراعية, 2021
اُستخدمت في هذا البحث ثلاث طرائق مختلفة من أجل قياس التوصيل الهيدروليكي المشبع للتربة (ks)، تشمل طريقة الضاغط المائي الثابت، طريقة المحاكاة باستخدام البرنامج Rosetta وطريقة Wind.
إياد سراي الدين
doaj  

Ultraviolet and visible photometry of asteroid (21) Lutetia using the Hubble Space Telescope [PDF]

, 2010
The asteroid (21) Lutetia is the target of a planned close encounter by the Rosetta spacecraft in July 2010. To prepare for that flyby, Lutetia has been extensively observed by a variety of astronomical facilities. We used the Hubble Space Telescope (HST)
A'Hearn, A. J. Steffl, Barucci, Barucci, Barucci, Belskaya, Bowell, C. R. Chapman, Chapman, Chapman, Clark, Colina, D. C. Slater, Fienga, Gaffey, H. A. Weaver, Henry, J-. L. Bertaux, J. D. Drummond, J. W. Parker, Keller, L. M. Feaga, Lazzarin, M. F. A'Hearn, M. J. Mutchler, Magri, Magri, McCord, Morrison, Mueller, Nedelcu, P. D. Feldman, Perna, Rivkin, Rivkin, Roettger, S. A. Stern, Shepard, Stern, Vernazza, Vernazza, W. J. Merline, Wagner, Zellner   +43 more
core   +2 more sources

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

AI Guided Protein Design for Next‐Generation Autogenic Engineered Living Materials

Advanced Intelligent Systems, EarlyView.
Autogenic engineered living materials (ELMs) integrate biology and materials science to create self‐regenerating and self‐healing materials. This perspective highlights emerging strategies in protein engineering and AI‐guided de novo design to expand the capabilities of autogenic ELMs.
Hoda M. Hammad, Anna M. Duraj‐Thatte
wiley   +1 more source