Results 71 to 80 of about 857,752 (305)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Static and Dynamic Performance Optimization of the AC Rotary Head Based on Stiffness-Mass Matching

Actuators
The AC rotary head, serving as a dual-axis direct-drive rotary actuation unit in five-axis CNC machine tools, integrates torque motors for A- and C-axis actuation, and its structural static and dynamic characteristics directly govern the actuation ...
Jiaming Liu, Qing Liu, Hao Zheng, Wentie Niu   +3 more
doaj   +1 more source

Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures

Asian Journal of Pharmaceutical Sciences, 2018
We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We plotted “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Here,
Takashi Osamura, Yoshiko Takeuchi, Risako Onodera, Masahiro Kitamura, Yoshiteru Takahashi, Kohei Tahara, Hirofumi Takeuchi   +6 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Rotary Performance

, 2012
Photo of a Rotary ...
Toledo Rotary Club
core  

Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press

Asian Journal of Pharmaceutical Sciences, 2017
We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We proposed plotting “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting ...
Takashi Osamura, Yoshiko Takeuchi, Risako Onodera, Masahiro Kitamura, Yoshiteru Takahashi, Kohei Tahara, Hirofumi Takeuchi   +6 more
doaj   +1 more source

High Performance Motion Control of Rotary Axis for Simultaneous Multi-axis Controlled Motions

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 2008
This paper describes the motion control techniques of rotary tables for 5-axis machining centers. Especially, in the machining of complex shapes such as impellers, three translational axes and two rotary ones are simultaneously controlled. A tilting rotary table powered by the worm gear is generally applied as the rotary axes for the 5-axis machining ...
Ryuta SATO, Daisuke ENDO, Masaomi TSUTSUMI   +2 more
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Enhancing gas-solid fluidized bed dryer performance with horizontal axis rotary agitators: a simulation approach

Journal of Engineering and Applied Science
High energy consumption in fluidized bed dryers (FBDs) remains a critical challenge for tea processing, largely due to poor fluidization quality of sticky, irregular, and non-uniform tea particles.
Sri Utami Handayani, Eflita Yohana, Mohammad Tauviqirrahman, Luhung Damarran Achmad, Seiji Fujiwara, Kwang-Hwan Choi, Wahyu Caesarendra   +6 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source