Results 31 to 40 of about 908,506 (299)

Reliability-Based Design Optimization Applied to a Rotor Supported by Hydrodynamic Bearings

Machines
Rotating machines are an important part of industrial equipment. It is essential to improve their performance while reducing the manufacturing, operating, and maintenance costs.
Helio Fiori de Castro, Eduardo Henrique de Paula, Laís Bittencourt Visnadi   +2 more
doaj   +1 more source

LMD Method and Multi-Class RWSVM of Fault Diagnosis for Rotating Machinery Using Condition Monitoring Information

Sensors, 2013
Timely and accurate condition monitoring and fault diagnosis of rotating machinery are very important to maintain a high degree of availability, reliability and operational safety.
Zhongjie Shen, Zhengjia He, Xuefeng Chen, Zhiwen Liu   +3 more
doaj   +1 more source

Calculation of Rotor Dynamic Coefficients for Labyrinth Seals

International Journal of Rotating Machinery, 1998
A single control volume, Iwatsubo based bulk flow method for the calculation of these coefficients is developed and implemented. The method herein uses a unique iterative technique to first identify the mass flow rate based on pressure drops across the ...
B. P. Williams, R. D. Flack
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Modified Hierarchical Multiscale Dispersion Entropy and its Application to Fault Identification of Rotating Machinery

IEEE Access, 2020
The rotating machinery possesses complicated structures and various fault types, whose health state monitoring is essential for the normal production and operation of the equipment.
Fuming Zhou, Jinxing Shen, Xiaoqiang Yang, Xiaolin Liu, Wuqiang Liu   +4 more
doaj   +1 more source

An Integrated Fault Diagnosis Method for Rotating Machinery Based on Smoothness Priors Approach Fluctuation Dispersion Entropy and Density Peak Clustering

Shock and Vibration, 2022
In order to fully excavate the fault feature information of rotating machinery and accurately recognize the fault category, a novel fault diagnosis method was proposed, which combines with smoothness priors approach (SPA), fluctuation dispersion entropy (
Hongping Ge, Zhaohui Huang, Huaying Liu
doaj   +1 more source

A Study of Fault Signal Noise Reduction Based on Improved CEEMDAN-SVD

Applied Sciences, 2023
In light of the challenges posed by the complex structural characteristics and significant coupling of vibration signals in rotating machinery, this study proposes an adaptive noise reduction method called Complete Ensemble Empirical Mode Decomposition ...
Sixia Zhao, Lisha Ma, Liyou Xu, Mengnan Liu, Xiaoliang Chen   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source