Results 41 to 50 of about 968,782 (237)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Modified Hierarchical Multiscale Dispersion Entropy and its Application to Fault Identification of Rotating Machinery

IEEE Access, 2020
The rotating machinery possesses complicated structures and various fault types, whose health state monitoring is essential for the normal production and operation of the equipment.
Fuming Zhou, Jinxing Shen, Xiaoqiang Yang, Xiaolin Liu, Wuqiang Liu   +4 more
doaj   +1 more source

A Study of Fault Signal Noise Reduction Based on Improved CEEMDAN-SVD

Applied Sciences, 2023
In light of the challenges posed by the complex structural characteristics and significant coupling of vibration signals in rotating machinery, this study proposes an adaptive noise reduction method called Complete Ensemble Empirical Mode Decomposition ...
Sixia Zhao, Lisha Ma, Liyou Xu, Mengnan Liu, Xiaoliang Chen   +4 more
doaj   +1 more source

Observations of acoustic emission activity during gear defect diagnosis. [PDF]

, 2003
It is widely recognised that acoustic emission (AE) is gaining ground as a non- destructive technique (NDT) for health diagnosis on rotating machinery.
Mba, David, Tim Toutountzakis, David Mba, Toutountzakis, Tim   +3 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

An Integrated Fault Diagnosis Method for Rotating Machinery Based on Smoothness Priors Approach Fluctuation Dispersion Entropy and Density Peak Clustering

Shock and Vibration, 2022
In order to fully excavate the fault feature information of rotating machinery and accurately recognize the fault category, a novel fault diagnosis method was proposed, which combines with smoothness priors approach (SPA), fluctuation dispersion entropy (
Hongping Ge, Zhaohui Huang, Huaying Liu
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Concurrent Fault Diagnosis for Rotating Machinery Based on Vibration Sensors

International Journal of Distributed Sensor Networks, 2013
Rotating machinery is widely used in modern industry. It is one of the most critical components in a variety of machinery and equipment. Along with the continuous development of science and technology, the structures of rotating machinery become of ...
Qing-Hua Zhang, Qin Hu, Guoxi Sun, Xiaosheng Si, Aisong Qin   +4 more
doaj   +1 more source