Results 41 to 50 of about 116,947 (262)

Rotation sets and actions on curves

open access: yesAdvances in Mathematics, 2022
30 pages, 3 ...
Bowden , Jonathan   +4 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Single Parameter Model for Galaxy Rotation Curves

open access: yesGalaxies
One key piece of evidence for dark matter is the rotation-curve problem: the disagreement between measured galactic rotation curves and their luminous mass.
Sophia N. Cisneros   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Critical curves of rotations

open access: yesIndagationes Mathematicae
21 pages, 4 ...
John A.G. Roberts   +2 more
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Kinematic Decomposition of the H i Gaseous Component in the Large Magellanic Cloud

open access: yesThe Astrophysical Journal, 2022
We perform a profile analysis of the combined H i data cube of the Large Magellanic Cloud (LMC) from observations with the Australia Telescope Compact Array and the Parkes radio telescope. For the profile analysis, we use a newly developed algorithm that
Se-Heon Oh   +3 more
doaj   +1 more source

The rotation curves of flattened Sérsic bulges [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 2008
7 pages, 4 figures.
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Testing Bose–Einstein condensate dark matter models with the SPARC galactic rotation curves data

open access: yesEuropean Physical Journal C: Particles and Fields, 2020
The nature of one of the fundamental components of the Universe, dark matter, is still unknown. One interesting possibility is that dark matter could exist in the form of a self-interacting Bose–Einstein Condensate (BEC).
Maria Crăciun, Tiberiu Harko
doaj   +1 more source

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