Results 31 to 40 of about 74,911 (267)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Acta Orthopaedica, 2017 Background and purpose — There are many techniques for placing the femoral component in correct rotational alignment in total knee arthroplasty (TKA), but only a few have been tested against the supposed gold standard, rotation determined by ...
Eirik Aunan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Acta Crystallographica Section E, 2009 The asymmetric unit of the title compound, [Cd(C30H31N3O6)2](PF6)2·3H2O, contains one half-cation with the CdII center situated on a twofold rotational axis, one hexafluoridophosphate anion and two uncoordinated water molecules, one of which is ...
Nadezhda M. Kurochkina +4 more
doaj +1 more source
In Vivo Analysis of the Dynamic Motion Stability Characteristics of Geese’s Neck
Biomimetics, 2022 The goose’s neck is an excellent stabilizing organ with its graceful neck curves and flexible movements. However, the stabilizing mechanism of the goose’s neck remains unclear.
Jiajia Wang +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Jixie chuandong, 2010 Based on the principles of Laser Doppler Displacement Measurement of rotational axis,the measurement and compensation of roational axis positioning error for CNC spiral bevel gear grinding machine are studied.The rotational axis positioning error of ...
唐进元, 龙云泽
doaj
An off-axis rotating atom trap
Optics Express, 2006 We present a novel configuration of a magneto-optical trap for cold atoms. The trap is very simple in design, employing only a small permanent magnet and an external Helmholtz bias coil. The trap's principal advantage is that the entire volume of the overlapping laser beams can be used for atom guiding and manipulation. An especially interesting effect
Wu, J., Mosacatelli, Frank, Oh, E.
openaire +3 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Signatures of Core-envelope Rotational Misalignment in the Mixed-mode Asteroseismology of Kepler-56
The Astrophysical JournalExisting asteroseismic rotational measurements assume that stars rotate around a single axis. However, tidal torques from misaligned companions, or their possible engulfment, may bring the rotational axis of a star's envelope out of alignment with its ...
J. M. Joel Ong
doaj +1 more source