Results 51 to 60 of about 1,005,816 (291)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Jixie chuandong, 2010 Based on the principles of Laser Doppler Displacement Measurement of rotational axis,the measurement and compensation of roational axis positioning error for CNC spiral bevel gear grinding machine are studied.The rotational axis positioning error of ...
唐进元, 龙云泽
doaj
Signatures of Core-envelope Rotational Misalignment in the Mixed-mode Asteroseismology of Kepler-56
The Astrophysical JournalExisting asteroseismic rotational measurements assume that stars rotate around a single axis. However, tidal torques from misaligned companions, or their possible engulfment, may bring the rotational axis of a star's envelope out of alignment with its ...
J. M. Joel Ong
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Numerical simulation in vertical wind axis turbine with pitch controlled blades [PDF]
, 2012 Wind energy is more and more used as a renewable energy source character. The present wind turbine is a small one which allows to be used on roofs or in gardens to light small areas like publicity boards, parking, roads or for water pumping, heating ...
SIMONET, Sophie +3 more
core
Carbene-catalyzed atroposelective synthesis of axially chiral styrenes
Nature Communications, 2022 Axially chiral styrenes bearing a chiral axis between a sterically non-congested acyclic alkene and an aryl ring are difficult to prepare due to low rotational barrier of the axis. Here the authors present a method to form axially chiral styrenes bearing
Jia-Lei Yan +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Rotational hypersurfaces in Lorentz-Minkowski 4-space [PDF]
, 2021 In this study, we study rotational hypersurfaces in 4-dimensional Lorentz-Minkowski space. We find the rotational hypersurfaces about spacelike axis according to Gaussian and mean curvatures in E-1(4) and give some results with the aid of the Gaussian ...
Mustafa ALTIN +3 more
core +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source