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Rotavirus

Baillière's Clinical Gastroenterology, 1990
Since their discovery in the 1970s, the human rotaviruses have been recognized as the most important cause of acute infectious gastroenteritis among infants and children worldwide. Rotavirus has been found to infect almost all mammalian and avian species tested, and is primarily a disease of the young.
Y A, Maldonado, R H, Yolken
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Rotavirus

Clinics in Laboratory Medicine, 2015
Group A rotavirus (RVA) is the major cause of acute gastroenteritis (AGE) in young children worldwide. Introduction of two live, attenuated rotavirus vaccines, Rotarix® and RotaTeq®, has dramatically reduced RVA-associated AGE and mortality. High-throughput, sensitive and specific techniques are required to rapidly diagnose and characterize rotavirus ...
Mathew D, Esona, Rashi, Gautam
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Impact of rotavirus vaccines on rotavirus disease

Expert Review of Anti-infective Therapy, 2012
Rotaviruses are the most common cause of acute gastroenteritis in young children worldwide. Both licensed rotavirus vaccines (Rotarix™ [RV1] and RotaTeq™ [RV5]) are effective and safe. Studies from countries that have included RV1 or RV5 in the national immunization programs have demonstrated their safety and sustained efficacy under real-life ...
Lepage, Philippe, Vergison, Anne
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Rotavirus gastroenteritis

Advances in Therapy, 2005
Rotavirus is the single most important cause of severe, dehydrating gastroenteritis in infants and young children worldwide. Rotavirus gastroenteritis is associated with high morbidity in developed countries and significant mortality in developing countries. Virtually all children are infected with rotavirus by 3 years of age.
James D. Kellner   +2 more
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The rotavirus vaccine

Current Opinion in Pediatrics, 1999
A rotavirus vaccine was recently licensed by the Food and Drug Administration and is likely to be recommended for use in all infants by both the Advisory Committee on Immunization Practices and the American Academy of Pediatrics. If used as recommended, the vaccine is likely to prevent much of the 500,000 physician visits, 50,000 hospitalizations, and ...
H F Clark, Paul A. Offit
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Rotavirus

Clinics in Laboratory Medicine, 1999
Rotavirus is the leading cause of nonbacterial gastroenteritis in young children and may infect neonates, older children, and adults as well. A large number of serogroups and types complicates the study, epidemiology, diagnosis, and prevention of rotaviral illness. Currently, routine diagnostic methods are satisfactory only for group A rotaviruses, and
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Rotavirus vaccines

Scandinavian Journal of Infectious Diseases, 2008
Two live attenuated oral rotavirus vaccines were licensed in 2006 for prevention of severe acute gastroenteritis in children: Rotarix (GSK), a human rotavirus vaccine with G1P[8] serotype characteristics and RotaTeq (Merck), a bovine-human reassortant vaccine expressing human G1-4 and P[8] antigens.
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The rotavirus genus

Comparative Immunology, Microbiology and Infectious Diseases, 1994
Human rotaviruses, discovered nearly 20 years ago, have been proven to be major cause of paediatric diarrhoeal disease morbidity and mortality. The clinical significance of these viruses stimulated basic studies on their biology, molecular and antigenic properties and epidemiology.
Gianfranco Donelli, Fabiana Superti
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Rotavirus viroplasms

2022
Rotavirus cell infection and immunofluorescence. MA-104 Clone 1 cells (American Type Culture Collection; ATCC:CRL-2378.1; RRID:CVCL_3846) were cultured in DMEM-RS media supplemented with 5% fetal bovine serum at 37°C and 5% CO2. Prior to infection, Rhesus rotavirus (RRV) was activated with trypsin (10 μg/ml) for 30 min at 37°C.
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ROTAVIRUS GASTROENTERITIS

Annual Review of Medicine, 1987
Rotaviruses have proven to be major causes of pediatric diarrheal disease morbidity and mortality worldwide. The past several years have yielded substantial new insights into these viruses, their epidemiology, and the mechanisms of host resistance to them.
A V, Bartlett   +3 more
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