Results 31 to 40 of about 49,675 (180)

Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis.

New England Journal of Medicine, 2006
BACKGROUND The safety and efficacy of an attenuated G1P[8] human rotavirus (HRV) vaccine were tested in a randomized, double-blind, phase 3 trial. METHODS We studied 63,225 healthy infants from 11 Latin American countries and Finland who received two ...
G. Ruiz-Palacios, I. Pérez-Schael, F. Velázquez, H. Abate, T. Breuer, S. C. Clemens, B. Cheuvart, F. Espinoza, P. Gillard, B. Innis, Y. Cervantes, A. Linhares, Pio López, M. Macias-Parra, E. Ortega-Barria, Vesta L Richardson, D. M. Rivera-Medina, Luis Rivera, B. Salinas, N. Pavía-Ruz, J. Salmerón, R. Rüttimann, J. Tinoco, Pilar Rubio, E. Núñez, M. Guerrero, J. Yarzábal, Silvia Damaso, N. Tornieporth, X. Sáez-Llorens, Rodrigo Vergara, T. Vesikari, A. Bouckenooghe, R. Clemens, B. De Vos, M. O’Ryan   +35 more
semanticscholar   +1 more source

Current and new rotavirus vaccines

Current Opinion in Infectious Diseases, 2019
Purpose of review As of 2019, four rotavirus vaccines have been prequalified by the WHO for use worldwide. This review highlights current knowledge regarding rotavirus vaccines available, and provides a brief summary of the rotavirus vaccine pipeline ...
Rachel M. Burke, J. Tate, Carl D. Kirkwood, A. Steele, Umesh D. Parashar   +4 more
semanticscholar   +1 more source

A Novel Rotavirus Reverse Genetics Platform Supports Flexible Insertion of Exogenous Genes and Enables Rapid Development of a High-Throughput Neutralization Assay

Viruses, 2023
Despite the success of rotavirus vaccines, rotaviruses remain one of the leading causes of diarrheal diseases, resulting in significant childhood morbidity and mortality, especially in low- and middle-income countries. The reverse genetics system enables
Jiajie Wei, Scott Radcliffe, Amanda Pirrone, Meiqing Lu, Yuan Li, Jason Cassaday, William Newhard, Gwendolyn J. Heidecker, William A. Rose II, Xi He, Daniel Freed, Michael Citron, Amy Espeseth, Dai Wang   +13 more
doaj   +1 more source

Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection

Nature Communications, 2018
Neonatal rotavirus infections are predominantly asymptomatic. While an association with gastrointestinal symptoms has been described in some settings, factors influencing differences in clinical presentation are not well understood.
S. Ramani, C. Stewart, C. Stewart, D. Laucirica, N. Ajami, B. Robertson, C. Autran, Dhairyasheel Shinge, Sandya B Rani, Sasirekha Anandan, Liya Hu, J. Ferreon, K. Kuruvilla, J. Petrosino, B. Prasad, L. Bode, Gagandeep Kang, G. Kang, M. Estes   +18 more
semanticscholar   +1 more source

Estimated impact of rotavirus vaccine on hospitalizations and deaths from rotavirus diarrhea among children <5 in Asia

Expert Review of Vaccines, 2018
Background: Of the 215,000 global deaths from rotavirus estimated in 2013, 41% occur in Asian countries. However, despite a recommendation for global rotavirus vaccination since 2009, only eight countries in Asia have introduced the rotavirus vaccine ...
Eleanor Burnett, Jacqueline E. Tate, Carl D. Kirkwood, E. Anthony S. Nelson, Mathuram Santosham, A. Duncan Steele, Umesh D. Parashar   +6 more
doaj   +1 more source

Clinical characteristics and complications of rotavirus gastroenteritis in children in east London: A retrospective case-control study. [PDF]

PLoS ONE, 2018
Rotavirus is the leading cause of acute gastroenteritis in children and is associated with neurological complications such as seizures and encephalopathy.
Konstantinos Karampatsas, Leanne Osborne, May-Li Seah, Cheuk Y W Tong, Andrew J Prendergast   +4 more
doaj   +1 more source

Effectiveness of Rotavirus Vaccination: A Systematic Review of the First Decade of Global Postlicensure Data, 2006–2016

Clinical Infectious Diseases, 2017
Two rotavirus vaccines, Rotarix (RV1) and RotaTeq (RV5), were licensed for global use in 2006. A systematic review of 48 peer- reviewed articles with postlicensure data from 24 countries showed a median RV1 vaccine effectiveness (VE) of 84%, 75%, and 57%
Christine L Jonesteller, Eleanor M. Burnett, Catherine Yen, J. Tate, U. Parashar   +4 more
semanticscholar   +1 more source

Rotavirus infections and their genotype distribution in Rwanda before and after the introduction of rotavirus vaccination

PLoS ONE, 2023
Rotavirus vaccination has reduced mortality and hospital admissions due to rotavirus diarrhoea, but its effect on rotavirus infections and the impact of rotavirus genotypes are still unclear. Real-time PCR was used to detect rotavirus and other pathogens
Jean-Claude Kabayiza, Staffan Nilsson, Maria Andersson   +2 more
doaj  

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Global Impact of Rotavirus Vaccination on Childhood Hospitalizations and Mortality From Diarrhea

Journal of Infectious Diseases, 2017
In 2006, 2 rotavirus vaccines were licensed. We summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent ...
Eleanor M. Burnett, Christine L Jonesteller, J. Tate, Catherine Yen, U. Parashar   +4 more
semanticscholar   +1 more source