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Towards a human rotavirus disease model
Current Opinion in Virology, 2012While the clinical importance of human rotavirus (RV) disease is well recognized and potent vaccines have been developed, our understanding of how human RV causes diarrhoea, vomiting and death remains unresolved. The fact that oral rehydration corrects electrolyte and water loss, indicates that enterocytes in the small intestine have a functional ...
Marie, Hagbom +3 more
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Characterization of a Group D Rotavirus
Avian Diseases, 1993A rotavirus isolated from the intestinal contents of commercial ring-neck pheasant chicks was determined to be a group D rotavirus based on its RNA electropherotype and its serologic relatedness to known turkey group A and D rotaviruses using immune electron microscopy and agar-gel immunodiffusion assays.
C M, Devitt, D L, Reynolds
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Rotavirus infection in a small community
Journal of Medical Virology, 1985AbstractSerial titres of rotavirus specific IgG and IgM have been measured in children and adults living in a small community over a 21/4‐year period. In all age groups the mean titres of rotavirus specific IgG and IgM rose and fell in parallel with the changes in frequency of gastroenteritis symptoms in the communily bul after the time when ...
M D, Holdaway +3 more
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A live attenuated human rotavirus vaccine
Drugs of Today, 2007Rotavirus infections are the leading cause of severe gastroenteritis in young children worldwide. This review provides a summary of the development of a live oral rotavirus vaccine, Rotarix (GlaxoSmithKline, Rixensart, Belgium) developed from a single protective G1P[8] human strain.
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INACTIVATION OF A ROTAVIRUS BY DISINFECTANTS
Medical Journal of Australia, 1981Rotavirus SA 11, clarified and in human faeces, was exposed to eight commonly used hospital and laboratory disinfectants for periods between 15 seconds and two hours. Of the three hard disinfectants tested, 0.95 by volume (95% v/v) ethanol and 0.05 by volume (5% v/v) Biogram were more effective in inactivating SA 11 than 4% (w/v) or 10% (w/v ...
J A, Tan, R D, Schnagl
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Nosocomial Rotavirus Infections: A Meta-analysis
Pediatrics, 2012BACKGROUND AND OBJECTIVES: Nosocomial rotavirus (nRV) infections represent an important part of rotavirus (RV)-associated morbidity. The incidence of nRV influences the estimated total RV disease burden, an important determinant of cost-effectiveness of RV vaccination programs.
Patricia, Bruijning-Verhagen +2 more
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A ROTAVIRUS STAPHYLOCOCCAL CO‐AGGLUTINATION TEST
Acta Pathologica Microbiologica Scandinavica Series B: Microbiology, 1983A simple and rapid staphylococcal co‐agglutination (SA) test for detection of rotavirus in human faecal specimens is described. A suspension of protein A‐containing staphylococci coated with a rabbit hyperimmune serum against the rotavirus strain of calf diarrhoeae virus was used as reagent. Before the SA test, the faecal specimens were absorbed with a
K, Skaug, K J, Figenschau, I, Orstavik
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CHINESE ADULT ROTAVIRUS IS A GROUP B ROTAVIRUS
The Lancet, 1985C M, Chen +3 more
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Challenges to Developing a Rotavirus Vaccine
Viral Immunology, 2018Rotavirus is the most important cause of gastroenteritis worldwide. In developing countries, the virus is a major cause of death in infants and young children. In the United States, before the licensure of vaccines, rotavirus infections accounted for ∼2.7 million cases of gastroenteritis annually.
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