Results 21 to 30 of about 48,570 (189)

Statins significantly repress rotavirus replication through downregulation of cholesterol synthesis

Gut Microbes, 2021
Rotavirus is the most common cause of severe diarrhea among infants and young children and is responsible for more than 200,000 pediatric deaths per year.
Shihao Ding, Bingting Yu, Anneke J. van Vuuren   +2 more
doaj   +1 more source

Rotavirus gastroenteritis in children hospitalized in northeastern Poland in 2006–2020: Severity, seasonal trends, and impact of immunization

International Journal of Infectious Diseases, 2021
Objectives: The introduction of the rotavirus vaccine in 2006 significantly reduced childhood incidence of acute gastroenteritis (AGE) worldwide. The rotavirus vaccine was included in Poland’s national immunization program in 2021.
Kacper Toczylowski, Katarzyna Jackowska, Dawid Lewandowski, Sandra Kurylonek, Marlena Waszkiewicz-Stojda, Artur Sulik   +5 more
doaj   +1 more source

Reduction in morbidity and mortality from childhood diarrhoeal disease after species A rotavirus vaccine introduction in Latin America : a review

Memorias do Instituto Oswaldo Cruz, 2011
Countries in Latin America were among the first to implement routine vaccination against species A rotavirus (RVA). We evaluate data from Latin America on reductions in gastroenteritis and RVA disease burden following the introduction of RVA vaccine ...
Rishi Desai, Lucia Helena de Oliveira, Umesh D Parashar, Benjamin Lopman, Jacqueline E Tate, Manish M Patel   +5 more
doaj   +1 more source

Results and prospects of rotavirus immunisation in the Russian Federation

Биопрепараты: Профилактика, диагностика, лечение, 2023
Scientific relevance. Rotavirus disease and its consequences remain a leading vaccine-preventable cause of mortality in young children. Russia has not yet included rotavirus immunisation in the national vaccination schedule, but paediatric rotavirus ...
A. S. Korovkin, G. M. Ignatyev
doaj   +1 more source

Rotavírus A em crianças de até três anos de idade, hospitalizadas com gastroenterite aguda em Campo Grande, Estado do Mato Grosso do Sul Rotavirus A among hospitalized infants, up to three years of age, with acute gastroenteritis in Campo Grande, State of Mato Grosso do Sul

Revista da Sociedade Brasileira de Medicina Tropical, 2007
Através da eletroforese em gel de poliacrilamida e do ensaio imunenzimático combinado para rotavírus e adenovirus, foram analisadas 380 amostras fecais de crianças com até 3 anos, hospitalizadas com diarréia aguda, entre maio de 2000 e janeiro de 2004 ...
Márcia Sueli Assis Andreasi, Sonia Maria Fernandes Batista, Inês Aparecida Tozetti, Cláudia Okanobo Ozaki, Mariana Menegusso Nogueira, Fabíola Souza Fiaccadori, Ana Maria Tavares Borges, Rodrigo Alessandro Togo Santos, Divina das Dores de Paula Cardoso   +8 more
doaj   +1 more source

Immunogenicity analysis of a composition of inactivated human rotavirus A strains in mice following immunisation

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Currently, rotavirus infection is prevented with live attenuated vaccines. However, international and Russian vaccination practices, as well as the physiological characteristics of paediatric patients, necessitate the development of ...
M. V. Kovrizhko, E. P. Kolpakova, D. S. Kolpakov, T. I. Tverdokhlebova, E. S. Kurbatov   +4 more
doaj   +1 more source

Molecular characterization of group A rotavirus before and after the introduction of vaccines in Brazil

Revista da Sociedade Brasileira de Medicina Tropical, 2015
INTRODUCTION:In this study, the molecular characteristics of group A rotavirus (RVA) were compared in samples obtained before and after RVA vaccine-introduction in Brazil.METHODS:Eighty samples were screened for the presence of RVA. Positive samples were
Tâmera Nunes Vieira Almeida, Fabíola Souza Fiaccadori, Menira Souza, Ana Maria Tavares Borges, Divina das Dôres de Paula Cardoso   +4 more
doaj   +1 more source

Maintaining Momentum for Rotavirus Immunization in Africa during the COVID-19 Era: Report of the 13th African Rotavirus Symposium

Vaccines, 2022
The 13th African Rotavirus Symposium was held as a virtual event hosted by the University of Nairobi, Kenya and The Kenya Paediatric Association on 3rd and 4th November 2021.
Frederick N. Were, Khuzwayo C. Jere, George E. Armah, M. Jeffrey Mphahlele, Jason M. Mwenda, A. Duncan Steele   +5 more
doaj   +1 more source

Rotavirus and autoimmunity [PDF]

Journal of Infection, 2020
Rotavirus, a major etiological agent of acute diarrhea in children worldwide, has historically been linked to autoimmunity. In the last few years, several physiopathological approaches have been proposed to explain the leading mechanism triggering autoimmunity, from the old concept of molecular mimicry to the emerging theory of bystander activation and
J, Gómez-Rial, I, Rivero-Calle, A, Salas, F, Martinón-Torres   +3 more
openaire   +2 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source