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Intussusception and rotavirus vaccines
Vaccine, 2006The association between the first oral rotavirus vaccine to be licensed in the U.S. (Rotashield) and intussusception has presented a major challenge to the effort to reduce the global burden related to rotavirus infection. Although the risk of developing intussusception following immunization with Rotashield is low, debate continues about the ...
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1996
We evaluated rotavirus subunit vaccines for use in humans and animals. Insect cells were co-infected with combinations of individual baculovirus recombinants expressing human, bovine or simian rotavirus VP2, VP4, VP6 or VP7 to produce virus-like particles (VLPs).
Conner, M.E. +9 more
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We evaluated rotavirus subunit vaccines for use in humans and animals. Insect cells were co-infected with combinations of individual baculovirus recombinants expressing human, bovine or simian rotavirus VP2, VP4, VP6 or VP7 to produce virus-like particles (VLPs).
Conner, M.E. +9 more
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Rotavirus vaccination programmes
BMJ, 2012Early results are promising and programmes should be adopted more widely In a linked research paper (doi:10.1136/bmj.e4752), Braeckman and colleagues analyse the effectiveness of a monovalent rotavirus vaccine after its routine introduction in Belgium.1 This is the first study of its kind from Europe, and the new data offer robust evidence on the ...
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Pediatric Infectious Disease Journal, 2011
: The current Belgian experience with rotavirus vaccination provides a unique perspective to look at the effect of vaccination. Shortly after introduction, a nation-wide recommendation was issued and despite the fact that both rotavirus vaccines are offered through partial reimbursement, vaccine uptake has already reached a high level (at least 90 ...
Braeckman, Tessa +5 more
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: The current Belgian experience with rotavirus vaccination provides a unique perspective to look at the effect of vaccination. Shortly after introduction, a nation-wide recommendation was issued and despite the fact that both rotavirus vaccines are offered through partial reimbursement, vaccine uptake has already reached a high level (at least 90 ...
Braeckman, Tessa +5 more
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The future of rotavirus vaccines
Seminars in Pediatric Infectious Diseases, 2002In 1998, a simian-human reassortant rotavirus vaccine was licensed and recommended for routine use in children. Within 1 year, however, the vaccine was found to be a cause of intussusception, estimated to be approximately 1 case per 10,000 immunized children, and the recommendations were withdrawn.
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Rotavirus Vaccination in Central Europe
Journal of Pediatric Gastroenterology and Nutrition, 2013ABSTRACTEach year, rotavirus (RV) infection is the leading cause of acute gastroenteritis requiring hospitalisation and of nosocomially transmitted diseases in children younger than 5 years across Central European Vaccination Awareness Group (CEVAG) countries; however, inadequate surveillance systems and lack of routine RV testing still exist in most ...
Mészner, Zsofia +16 more
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Pediatric Infectious Disease Journal, 2006
The twin objectives of all vaccines are safety and efficacy. In the case of rotavirus vaccine for humans safety and efficacy initially was sought through oral administration of related viruses indigenous to animals but the assumption that these viruses are harmless to humans appeared to be only partly correct.
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The twin objectives of all vaccines are safety and efficacy. In the case of rotavirus vaccine for humans safety and efficacy initially was sought through oral administration of related viruses indigenous to animals but the assumption that these viruses are harmless to humans appeared to be only partly correct.
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Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, 2014
Recently published pharmacoepidemiological studies associate the currently authorized Rotavirus (RV) vaccines with intussusception (IS). We aimed at investigating whether, in Germany, there are excess IS cases in RV vaccinees compared with the background incidence before market authorization in 2006.
D, Oberle +4 more
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Recently published pharmacoepidemiological studies associate the currently authorized Rotavirus (RV) vaccines with intussusception (IS). We aimed at investigating whether, in Germany, there are excess IS cases in RV vaccinees compared with the background incidence before market authorization in 2006.
D, Oberle +4 more
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Pediatrics, 2001
To the Editor. Dr Margaret Rennels' defense of the current vaccine licensure procedure (“The Rotavirus Vaccine Story: A Clinical Investigator's View,” Pediatrics. 2000;106:123–125) is very compelling and well-reasoned in regard to the association of intussusception with administration of the rotavirus vaccine.
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To the Editor. Dr Margaret Rennels' defense of the current vaccine licensure procedure (“The Rotavirus Vaccine Story: A Clinical Investigator's View,” Pediatrics. 2000;106:123–125) is very compelling and well-reasoned in regard to the association of intussusception with administration of the rotavirus vaccine.
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Annual Review of Medicine, 2006
Rotavirus is the single most common cause of acute, dehydrating gastroenteritis worldwide. This is a highly contagious and highly democratic disease. The attack rate in infants and young children is similar regardless of sanitation, socioeconomics or geography.
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Rotavirus is the single most common cause of acute, dehydrating gastroenteritis worldwide. This is a highly contagious and highly democratic disease. The attack rate in infants and young children is similar regardless of sanitation, socioeconomics or geography.
openaire +2 more sources