Results 101 to 110 of about 188,936 (312)
Advanced Science, EarlyView.THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu +10 more
wiley +1 more source
Noise of a model counterrotation propeller with reduced aft rotor diameter at simulated takeoff/approach conditions (F7/A3) [PDF]
A model high-speed advanced counterrotation propeller, F7/A3, was tested in the NASA Lewis Research Center 9 by 15 foot Anechoic Wind Tunnel at simulated takeoff/approach conditions of 0.2 Mach number.
Gordon, Eliott B., Woodward, Richard P.
core +1 more source
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
A simulation of rotor-stator interaction using the Euler equations and patched grids [PDF]
An unsteady Euler code to study rotor-stator interaction problem was developed. The code uses patched grids that move relative to each other to simulate the motion of the rotor airfoils with respect to the stator airfoils. The Osher integration scheme is
Rai, M. M.
core +1 more source
Advanced Science, EarlyView.A phosphorescent dye was designed to fit in a hand‐to‐glove fashion into the 1D‐pore channels of MIL‐68(In). We synthesized MIL‐68(In) as powder and thin films, loaded the dye into the pores with controlled packing, and found that the phosphorescence and quantum yield are enhanced.
Bahram Hosseini Monjezi +12 more
wiley +1 more source
Results in EngineeringVertical-axis wind turbines (VAWT) with Darrieus and Savonius rotors were studied based on the developed specialized package of computational aerodynamics.
Dmytro Redchyts +5 more
doaj +1 more source
Soft and Adhesive Cardiac Patch for Electrophysiological and Contraction Measurement
Advanced Science, EarlyView.This study developed an epicardial electronic patch with a modulus similar to that of the heart (approximately 65kPa), which can collect stable electrocardiogram signals and myocardial contractility on the surface of a dynamically beating heart. This is attributed to the hydrogen bond interaction formed between the amino and catechol groups in the ...
Wuliang Chen +10 more
wiley +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
International Journal of Rotating Machinery, 1999 The transient process which starts at the instability threshold of a rotor rotating in a fluid environment, and ends up in the limit cycle of self-excited vibrations known as fluid whirl or fluid whip, is discussed in this paper.
Agnes Muszynska
doaj +1 more source
Acoustic test of a model rotor and tail rotor: Results for the isolated rotors and combined configuration [PDF]
Acoustic data from a model scale main rotor and tail rotor experiment in the NASA Langley 14 by 22 Foot Subsonic Tunnel are presented for the main rotor and trail rotor in isolation and for the two rotors operating together. Results for the isolated main
Burley, C. L. +2 more
core +1 more source