Results 131 to 140 of about 2,952,202 (230)

Sailing Through Time: Building Pacific Maritime Resilience

open access: yesGlobal Policy, EarlyView.
ABSTRACT This article examines the Pacific Blue Shipping Partnership (PBSP), an ambitious initiative aimed at decarbonising maritime transport across Oceania. The study explores the cultural, historical and technological aspects of wind‐propelled shipping in the Pacific.
Christiaan De Beukelaer   +20 more
wiley   +1 more source

Advances in 4D Representation: Geometry, Motion, and Interaction

open access: yesComputer Graphics Forum, EarlyView.
We survey 4D representation through three key pillars — geometry, motion, and interaction — offering a selective, representation‐centric perspective to guide researchers in choosing and customizing the right 4D representation for their tasks. Abstract We present a survey on 4D generation and reconstruction, a fast‐evolving subfield of computer graphics
M. Zhao   +7 more
wiley   +1 more source

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

open access: yesThe FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels   +7 more
wiley   +1 more source

Resolving three GABA induced electrogenic events and GABA‐coupling stoichiometry for Na+ and Cl− in hGAT‐1

open access: yesThe FEBS Journal, EarlyView.
Using solid‐supported membrane electrophysiology, we resolved three electrogenic events during GABA transport by the human GAT‐1 transporter. A rapid occlusion step (E1) is followed by a GABA‐induced Na+ leak current (E2), which becomes prominent under steep Na+ gradients, and a slower current associated with Na+‐coupled GABA transport (E3 ...
Rocco Zerlotti   +8 more
wiley   +1 more source

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis

open access: yesThe FEBS Journal, EarlyView.
In this study, we investigate how flow constrictions and shear stress trigger cardiac antibody light chain (AL) fibril formation and deposition. We mimic the mechanical forces exerted by the heart and the microvasculature network using a mini‐peristaltic pump setup and a grid‐type microchannel network, respectively.
Yuji Goto   +11 more
wiley   +1 more source

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