Results 131 to 140 of about 175,294 (335)

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

open access: yesAdvanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang   +17 more
wiley   +1 more source

A Vectoring Thrust Coaxial Rotor for Micro Air Vehicle: Modeling, Design and Analysis [PDF]

open access: yes, 2013
The growing interest of rotary wing UAVs, for military and civilian applications, has encouraged designers to consider miniaturized configurations, more efficient in terms of endurance, payload capability and maneuverability. The purpose of this paper is
Moschetta, Jean-Marc, Prothin, Sebastien
core   +2 more sources

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

open access: yesAdvanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu   +14 more
wiley   +1 more source

Experimental comparison between a counter-rotating axial-flow fan and a conventional rotor-stator stage [PDF]

open access: yes, 2013
Based on the requirement of energy consumption level and weight and dimension restriction, compact axial machines are highly demanded in many industrial fields.
BAKIR, Farid   +2 more
core   +3 more sources

AI‐Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue

open access: yesAdvanced Science, EarlyView.
A fully integrated vibration‐assisted capsule is presented for the minimally invasive detection of bowel lesions. The capsule incorporates a wireless sensor and an eccentric motor to probe tissue mechanics in situ. By coupling triaxial vibration signals with AI‐based classification and analytical modeling, the system enables early, non‐visual ...
Xizheng Fang   +6 more
wiley   +1 more source

High Specification Offshore Blades: Work Package: 1B: Blades Design [PDF]

open access: yes, 2008
This report outlines the current state of the art in offshore wind turbine blade aerodynamic design, along with the key technical limitations and possible technologies which may improve the aerodynamic design of blades and turbine rotors in the future ...
Brown, Richard   +3 more
core  

Visualizing and Quantifying Impact with Mechanochromic Sensing Paints Based on Self‐Assembled Polydiacetylene‐Silk Core‐Shell Vesicles

open access: yesAdvanced Science, EarlyView.
Tracking physical impacts is important in many fields. Self‐assembled microparticles made from polydiacetylene and silk fibroin that change color from blue to red when hit can provide an alternative approach to traditional mechanical transducers, quantitatively visualizing impact with responses ranging from <100 to 770 N.
Marco Lo Presti   +4 more
wiley   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

open access: yesAdvanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang   +11 more
wiley   +1 more source

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