Results 41 to 50 of about 1,333,451 (280)

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

BOORrapporten 631

, 2021
In opdracht van Stadsontwikkeling van de gemeente Rotterdam heeft de afdeling Onderzoek en Rapportage van het Bureau Oudheidkundig Onderzoek Rotterdam (BOOR) van de gemeente Rotterdam in maart 2017 een verkennend inventariserend veldonderzoek uitgevoerd ...
Schiltmans, drs. D.E.A. (Archeologie Rotterdam (BOOR))
core   +1 more source

Through the lens of marketing authorization holders: experience in use of real‐world data and real‐world evidence in drug development and regulatory submissions in EU

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola, Aleksandar Gigov, Hubertus G. M. Leufkens, Andrew Bate, Marie Louise De Bruin, Helga Gardarsdottir   +5 more
wiley   +1 more source

Las gramáticas como textos polémicos: la controversia entre gramáticos de la lengua española en Francia a mediados del siglo xvii

Criticón, 2009
Common knowledge usually thinks that grammars are aseptic texts which simply describe the grammatical rules of a given language. Nevertheless, this is far from the truth: grammatical discourse has been filled over the time with outnumbered, traditional ...
Daniel M. Sáez Rivera
doaj   +1 more source

Turnover rates of personnel in an academic hospital ( Rotterdam ) 1975

, 2007
Acquaintance with activities of personnel clubs like P.C.O. and O.P.A.R. And with the journal the monitor / opinion on workers' participation and treatment of complaints / opinion on work situation in ward / kind of work / opinion on behaviour of ...
Pelkman, S., Sparreboom, A., Blume, P., Erasmus Universiteit Rotterdam * Rotterdam, Fac. sociale wetenschappen (primary investigator)
core   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

Article 47(2) of the Rotterdam Rules: Solution of old problems or a new confusion?

Poredbeno Pomorsko Pravo, 2013
The Rotterdam Rules, adopted by UNCITRAL in 2008, address a number of issues that have not been regulated by previous international conventions, such as the delivery of goods and the right of control.
Časlav Pejović
doaj  

BOORrapporten 715

, 2021
In opdracht van Stadsontwikkeling van de gemeente Rotterdam heeft het team Onderzoek en Rapportage van Archeologie Rotterdam op 8 en 9 december 2020 een verkennend inventariserend veldonderzoek uitgevoerd in het plangebied Gravenbuurt te Rotterdam, in de
Schiltmans, drs. D.E.A. (Archeologie Rotterdam (BOOR))
core   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source