Results 51 to 60 of about 7,430 (275)

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

From cramming to binge‐watching: Integrating documentary‐based assessment into a pharmacology and toxicology curriculum—a qualitative study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims In the context of pharmacology and toxicology education, there is a growing shift toward programmatic assessment models that prioritize longitudinal learning, reflection and development of higher‐order cognitive skills. As part of this transition, we are exploring alternative and more meaningful forms of assessment. This qualitative study
Narin Akrawi, Heleen van der Sijs, Floor van Rosse   +2 more
wiley   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

The Rotterdam Rules and International Trade Law /

, 2020
This book offers an original academic study of the Rotterdam Rules. It analyses the salient articles that will have an impact on international sale contracts governed by English law, including the most popularly used international law instruments, terms ...
Magklasi, Ioanna,
core  

Have there been any changes to the basis of responsibility of carriers in the international conventions on the carriage of goods by sea?

Zbornik Radova Pravnog Fakulteta u Splitu, 2011
From the first international convention on the equalization of certain rules on cargo vessels (Hague Rules) in 1924, to the Protocol on changes to the Hague Rules (Visby Rules) in 1968, and the United Nations Convention on the Carriage of Goods by Sea ...
Ivo Grabovac
doaj  

Developing Ethics and Standards in Action Research

Journal of Social Intervention, 2008
In a globalizing world, what role can social science research – particularly action research – play in order to address the risks of exclusion, poverty, social and physical insecurity and environmental deprivation? More specifically, how can this type of
Ben Boog, Meindert Slagter, Jacques Zeelen   +2 more
doaj   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

'Electronic transport records': assessing the contribution of the Rotterdam Rules to e-commerce

, 2012
The Rotterdam Rules is the first international maritime carriage of goods Convention that officially acknowledges electronic records of contracts of carriage and has devoted a separate chapter to their regulation.
Magklasi, Ioanna
core   +1 more source

The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia

BMJ Open, 2019
Introduction Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that impairs normal lung development, causing pulmonary hypertension (PH). PH in CDH newborns is the main determinant for morbidity and mortality.
Anne Greenough, Thomas Schaible, Neil Patel, Dick Tibboel, Arno van Heijst, Theodore Dassios, Joost van Rosmalen, Viviana Arreo, Yogen Singh, Karel Allegaert, Suzan Cochius-den Otter, Florian Kipfmueller, Maria Dolores Elorza, Ana Sanchez, Leopoldo Martinez, Carlos Labrandero, Pertierra Cortada, Jordi Clotet Caba, Marta Aguar, Ana Gimeno, Raquel Escrig, Irma Capolupo, Pietro Bagolan, Fabrizio Ciralli, Genny Raffaeli, Giacomo Cavallaro, Valentina Condò, Paul D. Losty, Marie Horan, Nimish V. Subhedar, Emma E. Williams, Jennifer B. Brandt, Alexandra Kreissl, Berndt Urlesberger, Carmen Mesas Burgos, Björn Frenckner, Björn Larrson, Carla Pinto, Joana Saldaha, Anne Debeer, Anne Smits, Ragnhild Emblem, Richard Keijzer, Yassar Elsayed, David Tingay, Ulrike Kraemer   +45 more
doaj   +1 more source

Through the lens of marketing authorization holders: experience in use of real‐world data and real‐world evidence in drug development and regulatory submissions in EU

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola, Aleksandar Gigov, Hubertus G. M. Leufkens, Andrew Bate, Marie Louise De Bruin, Helga Gardarsdottir   +5 more
wiley   +1 more source