Results 101 to 110 of about 1,619,251 (342)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Experimental Study of Dowel Bar Alternatives Based on Similarity Model Test
Advances in Materials Science and Engineering, 2017 In this study, a small-scaled accelerated loading test based on similarity theory and Accelerated Pavement Analyzer was developed to evaluate dowel bars with different materials and cross-sections.
Chichun Hu +4 more
doaj +1 more source
Mode I stress intensity factors for semi-elliptical fatigue cracks in curved round bars
Theoretical and applied fracture mechanics (Print), 2021 M. Aursand, B. Skallerud
semanticscholar +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Operational Development of φ210 mm Bar Products by 800 Blooming Mill
Teshugang, 2009 With round- large oval- box- flat box pass system to replace original round- flat- octagon- flat box pass system,and optimized reduction schedule to roll φ210 mm carbon and alloy steel bars from 350 mm×470 mm bloom by 800 blooming mill at Special Steel ...
孙东升, 于莉
doaj
Theoretical and applied fracture mechanics (Print), 2021 J. Alegre, I. I. Cuesta, A. Díaz
semanticscholar +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Influence of loading pattern in fatigue life for notched round bars subjected to bending-torsion
MATEC Web of Conferences, 2014 Fatigue behaviour of DIN 34CrNiMo6 lateral notched round bars subjected to in-phase bending-torsion loading was investigated. Experimental tests were conducted under constant amplitude loading with stress ratios close to zero.
Branco Ricardo, Costa J.D., Antunes F.V.
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source