Results 151 to 160 of about 1,619,251 (342)

Pilot Production of Narrow Hardenability Band Gear Steel 20CrMnTiH by 120 t Converter-LF+RH Process at Panzhihua Steel

Teshugang, 2007
The φ25～160 mm round bars of gear steel 20CrMnTiH-0.20～0.22C,0.25～0.31Si,0.93~ 1.00Mn,1.03~1. 15Cr,0.05~0.08Ti were pilot-produced by 120 t converter- 130t LF+RH-280mm×380mm bloom concasting - hot rolling process at Panzhihua Steel.
蒲学坤, 柯晓涛, 邓通武
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Fatigue life assessment of notched round bars under multiaxial loading based on the total strain energy density approach

Theoretical and applied fracture mechanics (Print), 2017
R. Branco, J. Costa, F. Berto, F. Antunes   +3 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Active-Passive Mode-Locked and Mechanically Q-switched Frequency Tunable Nd:Glass Laser [PDF]

, 1988
Penzkofer, Alfons, Schillinger, H.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Practice on Production of Gear Steel 20CrMoH by Converter- Bloom Concasting Process at Panzhihua Iron and Steel

Teshugang, 2005
The Φ25 ~ 60 mm round bars of gear steel 20CrMoH have been produced at Panzhihua Iron and Steel by 120 t top and bottom combined blown converter - LF + RH refining - 280 nun x 380 mm bloom concasting - hot rolling process.
蒲学坤
doaj  

Mesh size dependency on notch radius for FEM analysis of notched round bars under tension

, 2017
A. Cichański
semanticscholar   +1 more source