Results 71 to 80 of about 220,739 (296)

The value of otoendoscopy in the management of middle ear cholesteatoma

Journal of Research in Medical Sciences, 2015
Background: The surgical management of cholesteatoma is a controversial issue, particularly regarding intact-canal-wall mastoidectomy (ICWM) versus canal-wall-down mastoidectomy (CWDM).
Sayed Hamidreza Abtahi, Farzaneh Abootalebian, Mehrdad Rogha, Nezamoddin Berjis   +3 more
doaj   +1 more source

Micro Injection Molding of Drug-Loaded Round Window Niche Implants for an Animal Model Using 3D-Printed Molds

Pharmaceutics, 2023
A novel approach for the long-term medical treatment of the inner ear is the diffusion of drugs through the round window membrane from a patient-individualized, drug-eluting implant, which is inserted in the middle ear. In this study, drug-loaded (10 wt%
Robert Mau, Thomas Eickner, Gábor Jüttner, Ziwen Gao, Chunjiang Wei, Nicklas Fiedler, Volkmar Senz, Thomas Lenarz, Niels Grabow, Verena Scheper, Hermann Seitz   +10 more
doaj   +1 more source

Hearing Loss after Round Window Surgery in Mice Is due to Middle Ear Effusion [PDF]

Audiology and Neurotology, 2016
<b><i>Background:</i></b> Delivery of therapeutic agents directly through the round window (RW) offers promise for treating sensorineural hearing loss. However, hearing loss can result from the surgical approach itself, and the reasons for this are poorly understood.
Bovey Z, Zhu, Jasmine, Saleh, Kevin T, Isgrig, Lisa L, Cunningham, Wade W, Chien   +4 more
openaire   +2 more sources

Using the shortwave infrared to image middle ear pathologies [PDF]

, 2016
Visualizing structures deep inside opaque biological tissues is one of the central challenges in biomedical imaging. Optical imaging with visible light provides high resolution and sensitivity; however, scattering and absorption of light by tissue limits
Bawendi, Moungi G, Bruns, Oliver T., Carr, Jessica Ann, Valdez Vargas, Tulio   +3 more
core   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Middle ear vibrations with SMA prosthesis. Experimental research

MATEC Web of Conferences, 2018
The paper focuses on experimental research of a middle ear prosthesis made of shape memory alloy. The prosthesis provides better adjustment to individual patient than classical prosthesis.
Rusinek Rafal, Szymanski Marcin, Teresinski Grzegorz   +2 more
doaj   +1 more source

Protein transduction therapy into cochleae via the round window niche in guinea pigs

Molecular Therapy: Methods & Clinical Development, 2016
Cell-penetrating peptides (CPPs) are short sequences of amino acids that facilitate the penetration of conjugated cargoes across mammalian cell membranes, and as such, they may provide a safe and effective method for drug delivery to the inner ear ...
Hiroki Takeda, Takaomi Kurioka, Taku Kaitsuka, Kazuhito Tomizawa, Takeshi Matsunobu, Farzana Hakim, Kunio Mizutari, Toru Miwa, Takao Yamada, Momoko Ise, Akihiro Shiotani, Eiji Yumoto, Ryosei Minoda   +12 more
doaj   +1 more source

Diminished Signal‐to‐Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1−/y Autism Model

Advanced Science, EarlyView.
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou, Théo Gauvrit, Célien Vandromme, Alexandre Cornier, Anna Saint‐Jean, Yves Le Feuvre, Melanie Ginger, Andreas Frick   +7 more
wiley   +1 more source

Detectability index measures of binaural masking level difference across populations of inferior colliculus neurons. [PDF]

, 1997
In everyday life we continually need to detect signals against a background of interfering noise (the “cocktail party effect”): a task that is much easier to accomplish using two ears.
Jiang, D, McAlpine, D, Palmer, AR
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source