Results 1 to 10 of about 35,461 (280)

Sonoporation of the Round Window Membrane on a Sheep Model: A Safety Study [PDF]

Pharmaceutics, 2023
Sonoporation using microbubble-assisted ultrasound increases the permeability of a biological barrier to therapeutic molecules. Application of this method to the round window membrane could improve the delivery of therapeutics to the inner ear.
Sandrine Kerneis, Jean-Michel Escoffre, John J. Galvin, Ayache Bouakaz, Antoine Presset, Corentin Alix, Edward Oujagir, Antoine Lefèvre, Patrick Emond, Hélène Blasco, David Bakhos   +10 more
doaj   +4 more sources

Ultrasound‐microbubble cavitation facilitates adeno‐associated virus mediated cochlear gene transfection across the round‐window membrane [PDF]

Bioengineering & Translational Medicine, 2021
The round window of the cochlea provides an ideal route for delivering medicines and gene therapy reagents that can cross the round window membrane (RWM) into the inner ear.
Zhen Zhang, Zhengnong Chen, Liqiang Fan, Thomas Landry, Jeremy Brown, Zhiping Yu, Shankai Yin, Jian Wang   +7 more
doaj   +3 more sources

Dynamic properties of human round window membrane in auditory frequencies running head: Dynamic properties of round window membrane [PDF]

Medical Engineering and Physics, 2013
Round window is one of the two openings into cochlea from the middle ear. Mechanical properties of round window membrane (RWM) affect cochlear fluid motion and play an important role in the transmission of sound into cochlea. However, no measurement of mechanical properties of RWM has been reported because of the complication of its location and small ...
Xiangming Zhang, Rong Z Gan
exaly   +5 more sources

Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane [PDF]

International Journal of Nanomedicine, 2014
Zhan Yu,1,* Min Yu,2,* Zhimin Zhou,3 Zhibao Zhang,3 Bo Du,3 Qingqing Xiong3 1Second Artillery General Hospital, Beijing, 2Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, College of Basic Medicine, China Medical ...
Yu Z, Yu M, Zhou Z, Zhang Z, Du B, Xiong Q   +5 more
doaj   +4 more sources

Characterization of the Sheep Round Window Membrane. [PDF]

J Assoc Res Otolaryngol, 2021
Intratympanic injection is a clinically used approach to locally deliver therapeutic molecules to the inner ear. Drug diffusion, at least in part, is presumed to occur through the round window membrane (RWM), one of the two openings to the inner ear. Previous studies in human temporal bones have identified a three-layered structure of the RWM with a ...
Han S, Suzuki-Kerr H, Suwantika M, Telang RS, Gerneke DA, Anekal PV, Bird P, Vlajkovic SM, Thorne PR.   +8 more
europepmc   +4 more sources

Assessment of drug permeability through an ex vivo porcine round window membrane model [PDF]

iScience, 2023
Summary: Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is challenging. Systemic delivery is not effective as only a small fraction of the therapeutic agent reaches the inner ear.
Adele Moatti, Dylan Silkstone, Taylor Martin, Keith Abbey, Kendall A Hutson, Douglas C Fitzpatrick, Carlton J Zdanski, Alan G Cheng, Frances S Ligler, Alon Greenbaum   +9 more
doaj   +2 more sources

Development and Characterization of an In Vitro Round Window Membrane Model for Drug Permeability Evaluations [PDF]

Pharmaceuticals, 2022
Hearing loss and balance disorders are highly common disorders, and the development of effective oto-therapeutics remains an area of intense research.
Ruby Singh, Bhaskar Birru, Joachim G. S. Veit, Elizabeth M. Arrigali, Monica A. Serban   +4 more
doaj   +2 more sources

Critical Evaluation of Round Window Membrane Sealing in the Treatment of Idiopathic Sudden Unilateral Hearing Loss [PDF]

Clinical and Experimental Otorhinolaryngology, 2015
ObjectivesRupture of the round window membrane with consecutive development of a perilymphatic fistula (PLF) is still a matter of controversial debate in the pathogenesis of idiopathic sudden sensorineural hearing loss (SSHL).
Stephan Hoch, Thomas Vomhof, Afshin Teymoortash   +2 more
doaj   +2 more sources

Ultrastructural Changes Associated With the Enhanced Permeability of the Round Window Membrane Mediated by Ultrasound Microbubbles [PDF]

Frontiers in Pharmacology, 2020
The round window membrane (RWM) is the most common entryway for local drug and gene delivery into the inner ear, but its permeability can change the treatment outcome.
Yi-Chun Lin, Hsin-Chien Chen, Hang-Kang Chen, Yuan-Yung Lin, Yuan-Yung Lin, Chao-Yin Kuo, Hao Wang, Chia-Lien Hung, Cheng-Ping Shih, Chih-Hung Wang, Chih-Hung Wang, Chih-Hung Wang   +11 more
doaj   +2 more sources

Correlation between the stereostructure of facial recess and the classification of round window membrane visibility [PDF]

European Journal of Medical Research
Objectives This study investigates the correlation between the dimensions of the facial recess (FR) and the selection of an electrode array insertion approach in cochlear implantation. Study design Prospective clinical study.
Huimin Yang, Yongqiang Zhao, Hui Li, Jianqiu Chen   +3 more
doaj   +2 more sources