Assessment of drug permeability through an ex vivo porcine round window membrane model
iScience, 2023 Summary: Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is challenging. Systemic delivery is not effective as only a small fraction of the therapeutic agent reaches the inner ear.
Adele Moatti +9 more
doaj +1 more source
Diagnostic Performance of Endoscopic and Microscopic Procedures for Identifying Different Middle Ear Structures and Remaining Disease in Patients with Chronic Otitis Media: A Prospective Cohort Study. [PDF]
PLoS ONE, 2015 BACKGROUND:The diagnostic performance of endoscopic and microscopic procedures for detecting diseases of the middle ear in patients with chronic otitis media (COM) has rarely been investigated. This study was conducted to compare the performance of these
Farhad Farahani +3 more
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Pharmacokinetics of sodium thiosulfate in Guinea pig perilymph following middle ear application
Journal of Otology, 2018 Hypothesis: To determine the pharmacokinetics of sodium thiosulfate in the inner ear perilymph following middle ear application in Guinea pigs. Background: Cisplatin chemotherapy is often associated with a dose-dependent high frequency sensorineural ...
Ronald J. Schroeder, II +3 more
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Micro-endoscopic ear anatomy of guinea pig applied to experimental surgery [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE: To describe topographic and endoscopic anatomy of guinea pig ear for development of surgical approaches in experimental studies. METHODS: Experimental study. Eight adult guinea pigs (Cavia porcellus) were used in this study.
Bruno Borges de Carvalho Barros +6 more
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The value of otoendoscopy in the management of middle ear cholesteatoma
Journal of Research in Medical Sciences, 2015 Background: The surgical management of cholesteatoma is a controversial issue, particularly regarding intact-canal-wall mastoidectomy (ICWM) versus canal-wall-down mastoidectomy (CWDM).
Sayed Hamidreza Abtahi +3 more
doaj +1 more source
Middle ear vibrations with SMA prosthesis. Experimental research
MATEC Web of Conferences, 2018 The paper focuses on experimental research of a middle ear prosthesis made of shape memory alloy. The prosthesis provides better adjustment to individual patient than classical prosthesis.
Rusinek Rafal +2 more
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Protein transduction therapy into cochleae via the round window niche in guinea pigs
Molecular Therapy: Methods & Clinical Development, 2016 Cell-penetrating peptides (CPPs) are short sequences of amino acids that facilitate the penetration of conjugated cargoes across mammalian cell membranes, and as such, they may provide a safe and effective method for drug delivery to the inner ear ...
Hiroki Takeda +12 more
doaj +1 more source
Experimental Visualization of Labyrinthine Structure with Optical Coherence Tomography [PDF]
Iranian Journal of Otorhinolaryngology, 2017 Introduction:Visualization of inner ear structures is a valuable strategy for researchers and clinicians working on hearing pathologies. Optical coherence tomography (OCT) is a high-resolution imaging technology which may be used for the visualization of
Saleh Mohebbi +5 more
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Round Window Niche and Membrane Dimensions: A Systematic Review
Audiology ResearchBackground/Objectives: To review the dimensions of the round window region (round window niche, bony structures surrounding the niche, and the membrane itself). Methods: Medline, EMBASE, Cochrane Library, and Google Scholar databases were searched by two
Mathieu Marx +4 more
doaj +1 more source
Brain SciencesIntroduction: Based on clinical practice guidelines, the application of corticosteroids as a first-line therapy is common. Although sudden sensorineural hearing loss (SSHL) etiology is primarily idiopathic, hearing loss can result from a perilymphatic ...
Alexander Kilgue +6 more
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