Results 11 to 20 of about 220,739 (296)

Numerical Study and Optimization of a Novel Piezoelectric Transducer for a Round-Window Stimulating Type Middle-Ear Implant

Micromachines, 2019
Round window (RW) stimulation is a new application of middle ear implants for treating hearing loss, especially for those with middle ear disease. However, most reports on it are based on the use of the floating mass transducer (FMT), which was not ...
Houguang Liu, Hehe Wang, Zhushi Rao, Jianhua Yang, Shanguo Yang   +4 more
doaj   +3 more sources

Mathematical modeling for local trans-round window membrane drug transport in the inner ear [PDF]

Drug Delivery, 2016
The structure and composition of the round window membrane (RWM) make it a particularly effective pathway for drug delivery to the inner ear. Therefore, predicting the efficiency of RWM transport would provide useful information for enhancing local application. In the present study, a mathematical model was established to achieve this goal. A series of
Yue, Zhang, Huanpeng, Su, Lu, Wen, Fan, Yang, Gang, Chen   +4 more
openaire   +4 more sources

Effect of Underwater Insertion on Intracochlear Pressure

Frontiers in Surgery, 2020
Background: The importance of intracochlear pressure during cochlear electrode insertion for the preservation of residual hearing has been widely discussed.
Conrad Riemann, Holger Sudhoff, Ingo Todt   +2 more
doaj   +1 more source

Sonoporation of the Round Window Membrane on a Sheep Model: A Safety Study

Pharmaceutics, 2023
Sonoporation using microbubble-assisted ultrasound increases the permeability of a biological barrier to therapeutic molecules. Application of this method to the round window membrane could improve the delivery of therapeutics to the inner ear.
Sandrine Kerneis, Jean-Michel Escoffre, John J. Galvin, Ayache Bouakaz, Antoine Presset, Corentin Alix, Edward Oujagir, Antoine Lefèvre, Patrick Emond, Hélène Blasco, David Bakhos   +10 more
doaj   +1 more source

Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter? [PDF]

PLoS ONE, 2018
INTRODUCTION:Middle ear application of gentamicin is a common medical treatment for uncontrolled Ménière's disease. The objective of the study was to evaluate the impact of endolymphatic hydrops on inner ear delivery.
Pedro Marques, Maoli Duan, Nicolas Perez-Fernandez, Jorge Spratley   +3 more
doaj   +1 more source

Case report: Perilymphatic fistula from a round window microfissure

Frontiers in Neurology, 2023
A microfissure near the round window niche is an anatomical structure that communicates between middle ear and the ampulla of the posterior semicircular canal.
Toru Seo, Arata Kemmochi, Yosuke Koike, Mizuho Aomi, Tatsuya Shinohe, Manabu Komori   +5 more
doaj   +1 more source

Case Report: Local Anesthesia Round Window Plugging and Simultaneous Vibrant Soundbridge Implant for Superior Semicircular Canal Dehiscence

Frontiers in Neurology, 2020
The aim of the present study is to report the outcomes of round window reinforcement surgery performed with the application of a Vibrant Soundbridge middle ear implant (VSB; MED-EL) in a patient with superior semicircular canal dehiscence (SSCD) who ...
Giulia Mignacco, Lorenzo Salerni, Ilaria Bindi, Giovanni Monciatti, Alfonso Cerase, Marco Mandalà   +5 more
doaj   +1 more source

Distribution of lipid nanocapsules in different cochlear cell populations after round window membrane permeation [PDF]

, 2008
Hearing loss is a major public health problem, and its treatment with traditional therapy strategies is often unsuccessful due to limited drug access deep in the temporal bone. Multifunctional nanoparticles that are targeted to specified cell populations,
E. Toppila, I. Pyykko, J. Zou, P. Saulnier, T. Manninen, T. Perrier, Y. Zhang   +6 more
core   +2 more sources

Round window membrane extracellular vesicles facilitate inner ear drug delivery

Journal of Controlled Release
S. Holdsclaw, D. Silkstone, F. Moazzam, H. Jeanneret, N. Tehsin, E. Norris, E. Talic, K. Popowski, G. Cruse, K. Cheng, A. Moatti   +10 more
openaire   +3 more sources

Critical Evaluation of Round Window Membrane Sealing in the Treatment of Idiopathic Sudden Unilateral Hearing Loss [PDF]

Clinical and Experimental Otorhinolaryngology, 2015
ObjectivesRupture of the round window membrane with consecutive development of a perilymphatic fistula (PLF) is still a matter of controversial debate in the pathogenesis of idiopathic sudden sensorineural hearing loss (SSHL).
Stephan Hoch, Thomas Vomhof, Afshin Teymoortash   +2 more
doaj   +1 more source