Results 41 to 50 of about 35,461 (280)

An investigation of cochlear dynamics in surgical and implanation processes [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The aim of this research is to improve the understanding of the impact on the cochlear dynamics corresponding to surgical tools, processes and hearing ...
Zoka Assadi, Masoud
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Distribution of lipid nanocapsules in different cochlear cell populations after round window membrane permeation [PDF]

, 2008
Hearing loss is a major public health problem, and its treatment with traditional therapy strategies is often unsuccessful due to limited drug access deep in the temporal bone. Multifunctional nanoparticles that are targeted to specified cell populations,
Y. Zhang, T. Perrier, J. Zou, I. Pyykko, P. Saulnier, E. Toppila, T. Manninen   +6 more
core   +3 more sources

The Role of Inflammatory Mediators in the Pathogenesis of Otitis Media and Sequelae [PDF]

Clinical and Experimental Otorhinolaryngology, 2008
This review deals with the characteristics of various inflammatory mediators identified in the middle ear during otitis media and in cholesteatoma. The role of each inflammatory mediator in the pathogenesis of otitis media and cholesteatoma has been ...
Steven K. Juhn, Min-Kyo Jung, Mark D. Hoffman, Brian R. Drew, Diego A. Preciado, Nicholas J. Sausen, Timothy T.K. Jung, Bo Hyung Kim, Sang-Yoo Park, Jizhen Lin, Frank G. Ondrey, David R. Mains, Tina Huang   +12 more
doaj   +1 more source

The Round Window Membrane in Otitis Media [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2008
To determine whether mutants of Streptococcus pneumoniae that are deficient in pneumococcal surface protein A (PspA), pneumococcal surface antigen A (PsaA), or pneumolysin (Ply) are less virulent and less likely to penetrate the round window membrane (RWM).Histopathologic comparison of wild-type S.
Patricia, Schachern, Vladimir, Tsuprun, Sebahattin, Cureoglu, Patricia, Ferrieri, David, Briles, Michael, Paparella, Steven, Juhn   +6 more
openaire   +2 more sources

Cochlear aqueduct flow resistance depends on round window membrane position in guinea pigs [PDF]

, 2004
The resistance for fluid flow of the cochlear aqueduct was measured in guinea pigs for different positions of the round window membrane. These different positions were obtained by applying different constant pressures to the middle car cavity. Fluid flow
Wit, HP; id_orcid, Albers, FWJ, Segenhout, JM, Feijen, RA, Wit, HP   +4 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Drug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations

Drug Delivery, 2021
The cochlea’s inaccessibility and complex nature provide significant challenges to delivering drugs and other agents uniformly, safely and efficiently, along the entire cochlear spiral. Large drug concentration gradients are formed along the cochlea when
Samuel M. Flaherty, Ian J. Russell, Andrei N. Lukashkin   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Preoperative Predictors of round window visibility on High resolution CT-scan temporal bone in patients undergoing cochlear implant surgery: A Systematic Review

Journal of the Pakistan Medical Association
Objective: To evaluate the correlation of high-resolution computed tomography-based radiological predictors with the surgical ease of access to the round window membrane in cochlear implant surgery.
Syed Akbar Abbas, Muhammad Wasif, Abdul Basit Shah Vardag, Haissan Iftikhar, Huzaifa Moiz, Syed Shabbir Afzal   +5 more
doaj   +1 more source