Proposal of a Theoretically Feasible Method to Perform Perilymph Sampling in Clinical Settings [PDF]
LifeThe ability to analyze perilymph could allow inner ear pathologies to be studied. However, today, perilymph sampling is only performed for research purposes because of the risk of negative outcomes such as hearing loss or balance disorders.
Arianna di Stadio +2 more
exaly +6 more sources
Proteome of normal human perilymph and perilymph from people with disabling vertigo.
PLoS ONE, 2019 The vast majority of hearing loss, the most common sensory impairment, and vertigo, which commonly causes falls, both reflect underlying dysfunction of inner ear cells.
Hsiao-Chun Lin +4 more
doaj +5 more sources
Brain SciencesRecent evidence shows that it is possible to identify the elements responsible for sensorineural hearing loss, such as pro-inflammatory cytokines and macrophages, by performing perilymph sampling.
Arianna di Stadio +2 more
exaly +4 more sources
Metabolites, 2019 Perilymph metabolomic analysis is an emerging innovative strategy to improve our knowledge of physiopathology in sensorineural hearing loss. This study aims to develop a metabolomic profile of human perilymph with which to evaluate the relationship ...
Hélène Blasco +2 more
exaly +4 more sources
Secretion of cochlin-tomoprotein (LCCL) in the middle ear following acute tympanic injury: implications for perilymph fistula diagnosis [PDF]
Frontiers in NeurologyIntroductionCochlin is the most abundant protein in the inner ear. The cleaved N-terminal domain of cochlin, known as LCCL and referred to as CTP (cochlin tomoprotein) in clinical biomarker usage, is a perilymph-specific protein and is widely used as a ...
Seong Hoon Bae +12 more
doaj +4 more sources
PLoS ONE, 2022 Modern proteomic analysis and reliable surgical access to gain liquid inner ear biopsies have enabled in depth molecular characterization of the cochlea microenvironment.
Martin Durisin +8 more
doaj +4 more sources
Proteome of Human Perilymph [PDF]
Journal of Proteome Research, 2011 Current diagnostic tools limit a clinician's ability to discriminate between many possible causes of sensorineural hearing loss. This constraint leads to the frequent diagnosis of the idiopathic condition, leaving patients without a clear prognosis and only general treatment options.
João A Paulo +2 more
exaly +3 more sources
MRI-based measurement of inner ear fluids reveals increased endolymph volume variability in patients with endolymphatic hydrops and hearing instability [PDF]
Scientific ReportsLack of proven biomarkers for hearing instability (HI) disorders leads to difficulty and delays in diagnosis. Given the association of HI with endolymphatic hydrops (EH), imaging-based techniques for quantification of endolymph and perilymph may be ...
Julia Telischi +8 more
doaj +2 more sources
Distinct MicroRNA Profiles in the Perilymph and Serum of Patients With Menière's Disease
Frontiers in Neurology, 2021 Hypothesis: Menière's disease microRNA (miRNA) profiles are unique and are reflected in the perilymph and serum of patients.Background: Development of effective biomarkers for Menière's disease are needed. miRNAs are small RNA sequences that downregulate
Matthew Shew +4 more
doaj +1 more source
Significance of Pseudo-Conductive Hearing Loss and Positional Nystagmus for Perilymphatic Fistula: Are They Related to Third-Window Effects? [PDF]
Clinical and Experimental Otorhinolaryngology, 2021 Objectives Patients’ clinical presentation is critical for identifying suspected perilymphatic fistula (PLF). The involvement of third-window lesions in the pathomechanism of PLF has been hypothesized. This study investigated the clinical features of PLF
Jong Sei Kim +4 more
doaj +1 more source