Proposal of a Theoretically Feasible Method to Perform Perilymph Sampling in Clinical Settings [PDF]
LifeThe ability to analyze perilymph could allow inner ear pathologies to be studied. However, today, perilymph sampling is only performed for research purposes because of the risk of negative outcomes such as hearing loss or balance disorders.
Federico Maria Gioacchini +2 more
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Proteome of normal human perilymph and perilymph from people with disabling vertigo.
PLoS ONE, 2019 The vast majority of hearing loss, the most common sensory impairment, and vertigo, which commonly causes falls, both reflect underlying dysfunction of inner ear cells.
Hsiao-Chun Lin +4 more
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Metabolites, 2019 Perilymph metabolomic analysis is an emerging innovative strategy to improve our knowledge of physiopathology in sensorineural hearing loss. This study aims to develop a metabolomic profile of human perilymph with which to evaluate the relationship ...
Thuy-Tran Trinh +2 more
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The missing perilymph sign on MRI indicates a perilymphatic fistula: A case report [PDF]
Journal of OtologyA perilymphatic fistula (PLF) is a rare condition in which perilymph leaks from the cochlea or vestibule into the surrounding cavities, most commonly through round and oval windows, and causes cochlear and vestibular symptoms. However, vague symptoms and
Jing Zou, Hongbi Li
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Brain SciencesRecent evidence shows that it is possible to identify the elements responsible for sensorineural hearing loss, such as pro-inflammatory cytokines and macrophages, by performing perilymph sampling.
Arianna Di Stadio +2 more
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Secretion of cochlin-tomoprotein (LCCL) in the middle ear following acute tympanic injury: implications for perilymph fistula diagnosis [PDF]
Frontiers in NeurologyIntroductionCochlin is the most abundant protein in the inner ear. The cleaved N-terminal domain of cochlin, known as LCCL and referred to as CTP (cochlin tomoprotein) in clinical biomarker usage, is a perilymph-specific protein and is widely used as a ...
Seong Hoon Bae +12 more
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MRI-based measurement of inner ear fluids reveals increased endolymph volume variability in patients with endolymphatic hydrops and hearing instability [PDF]
Scientific ReportsLack of proven biomarkers for hearing instability (HI) disorders leads to difficulty and delays in diagnosis. Given the association of HI with endolymphatic hydrops (EH), imaging-based techniques for quantification of endolymph and perilymph may be ...
Julia Telischi +8 more
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Protein profile of mouse endolymph suggests a role in controlling cochlear homeostasis [PDF]
iScienceSummary: The cochlea contains two extracellular fluids, perilymph and endolymph. Endolymph exhibits high potential of approximately +80 to +110 mV (depending on species), which sensitizes sensory hair cells.
Masatoshi Fukuda +11 more
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Effect of Intracochlear Brain-Derived Neurotrophic Factor on Guinea Pig Sensorineural Hearing Loss [PDF]
Journal of Otolaryngology - Head and Neck SurgeryImportance This study investigates the potential of brain-derived neurotrophic factor (BDNF) as treatment for sensorineural hearing loss (SNHL) in a guinea pig model to potentially advance hearing restoration strategies. The correlation between oxidation-
Deanna Gigliotti MD, MSc, FRCSC +1 more
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Distinct MicroRNA Profiles in the Perilymph and Serum of Patients With Menière's Disease
Frontiers in Neurology, 2021 Hypothesis: Menière's disease microRNA (miRNA) profiles are unique and are reflected in the perilymph and serum of patients.Background: Development of effective biomarkers for Menière's disease are needed. miRNAs are small RNA sequences that downregulate
Matthew Shew +4 more
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