Results 31 to 40 of about 5,257 (207)

Personalized Proteomics for Precision Diagnostics in Hearing Loss: Disease-Specific Analysis of Human Perilymph by Mass Spectrometry [PDF]

open access: yes, 2021
Despite a vast amount of data generated by proteomic analysis on cochlear fluid, novel clinically applicable biomarkers of inner ear diseases have not been identified hitherto.
Andreas Pich   +15 more
core   +3 more sources

Long-Term in vivo Release Profile of Dexamethasone-Loaded Silicone Rods Implanted Into the Cochlea of Guinea Pigs

open access: yesFrontiers in Neurology, 2020
Glucocorticoids are used intra-operatively in cochlear implant surgeries to reduce the inflammatory reaction caused by insertion trauma and the foreign body response against the electrode carrier after cochlear implantation.
Arne Liebau   +9 more
doaj   +1 more source

Facilitated transfer of glucose from blood into perilymph in the rat cochlea [PDF]

open access: yes, 1987
The transport of glucose into cochlear endolymph, perilymph of scala vestibuli and perilymph of scala tympani, and cerebrospinal fluid (CSF) was studied after intravenous administration of tracers of D-glucose, L-glucose, and 3-O-methyl-D-glucose in ...
C. Amiel   +4 more
core   +1 more source

Dual viscosity mixture vehicle for intratympanic steroid treatment modifies the ROS and inflammation related proteomes

open access: yesFrontiers in Pharmacology, 2023
Until recently, the most standard treatment for sensorineural or sudden hearing loss, which is caused by inner ear damage or deterioration, has been systemic oral steroid administration.
Jin Woo Jung   +8 more
doaj   +1 more source

K, Cl, and H2O entry in endolymph, perilymph, and cerebrospinal fluid of the rat [PDF]

open access: yes, 1982
The kinetics of radioactive potassium, chloride, and water entry into endolymph, perilymph, and cerebrospinal fluid were studied after intravenous administration of tracers in anesthetized and nephrectomized rats.
C. Amiel   +3 more
core   +1 more source

MicroRNA Profiling in the Perilymph of Cochlear Implant Patients: Identifying Markers that Correlate to Audiological Outcomes [PDF]

open access: yes, 2021
MicroRNA (miRNA) expression profiles from human perilymph correlate to post cochlear implantation (CI) hearing outcomes.  The high inter-individual variability in speech perception among cochlear implant recipients is still poorly understood.
Prentiss, Sandra   +5 more
core   +1 more source

Utility of cochlear perilymph biomarkers for hearing loss - A systematic review. [PDF]

open access: yesPLoS One
The live cochlea is a critical and delicate sensory organ with tissue sampling posing a risk to balance and hearing functions. Consequently, a researchers' ability to investigate the pathogenesis of sensorineural hearing loss (SNHL) has been limited ...
Wanniarachchi K   +4 more
europepmc   +3 more sources

Cyclo-oxygenase enzyme in the perilymph of human inner ear. [PDF]

open access: yes, 2010
Conclusions: Cyclo-oxygenase-2 (COX-2) enzyme would not appear to be constitutively expressed in human perilymph while it is always induced in the perilymph of patients affected by sensorineural hearing loss (SNHL).
Edoardo Covelli   +13 more
core   +1 more source

Metabolomic Studies in Inner Ear Pathologies

open access: yesMetabolites, 2022
Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired.
Luc Boullaud   +3 more
doaj   +1 more source

Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear

open access: yesFrontiers in Cellular Neuroscience, 2019
Some forms of triamcinolone may provide alternate options for local therapy of the inner ear in addition to the steroids currently in use. We compared the perilymph pharmacokinetics of triamcinolone-acetonide, triamcinolone, and dexamethasone, each ...
Alec Nicholas Salt   +3 more
doaj   +1 more source

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