Results 31 to 40 of about 5,243 (207)

Metabolomic Studies in Inner Ear Pathologies

Metabolites, 2022
Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired.
Luc Boullaud, Hélène Blasco, Thuy-Trân Trinh, David Bakhos   +3 more
doaj   +1 more source

Fístula perilinfática em cobaias: comparação entre evolução natural e correção cirúrgica Perilymphatic fistula in guinea pigs: natural evolution versus surgical treatment

Brazilian Journal of Otorhinolaryngology, 2010
As fístulas perilinfáticas ainda constituem um grande desafio quanto ao seu tratamento. Em alguns casos, seu fechamento cirúrgico pode reduzir as sequelas auditivas e vestibulares.
Ektor Tsuneo Onishi, Yotaka Fukuda
doaj   +1 more source

Major protein categories in human perilymph.

, 2019
(A) The perilymph of patients with intact hearing. Within each category, the percentage of the total amount of proteins is denoted within each bar. The Other category included proteins involved in ubiquitination, blood coagulation cascade, and receptors.
Yin Ren (550805), Hsiao-Chun Lin (6824516), Shyan-Yuan Kao (2172874), Konstantina M. Stankovic (2172877), Andrew C. Lysaght (632367)   +4 more
core   +1 more source

Dye Tracking Following Posterior Semicircular Canal or Round Window Membrane Injections Suggests a Role for the Cochlea Aqueduct in Modulating Distribution

Frontiers in Cellular Neuroscience, 2019
The inner ear houses the sensory epithelium responsible for vestibular and auditory function. The sensory epithelia are driven by pressure and vibration of the fluid filled structures in which they are embedded so that understanding the homeostatic ...
Sara Talaei, Michael E. Schnee, Ksenia A. Aaron, Anthony J. Ricci, Anthony J. Ricci   +4 more
doaj   +1 more source

Proteomic analysis of human perilymph.

, 2019
(A) Principal component analysis (PCA) of the normalized and log-transformed spectral count matrix from the 6 samples of perilymph, including 3 from patients with normal hearing (pseudocolored green) and 3 from patients with severe vestibular dysfunction
Yin Ren (550805), Hsiao-Chun Lin (6824516), Shyan-Yuan Kao (2172874), Konstantina M. Stankovic (2172877), Andrew C. Lysaght (632367)   +4 more
core   +1 more source

Proteome of Human Perilymph

, 2016
Current diagnostic tools limit a clinician’s ability to discriminate between many possible causes of sensorineural hearing loss. This constraint leads to the frequent diagnosis of the idiopathic condition, leaving patients without a clear prognosis and ...
Saumil N. Merchant (2172880), Hanno Steen (383933), Shyan-Yuan Kao (2172874), Konstantina M. Stankovic (2172877), Joao A. Paulo (397190), Andrew C. Lysaght (632367)   +5 more
core   +1 more source

A Window of Opportunity: Perilymph Sampling from the Round Window Membrane Can Advance Inner Ear Diagnostics and Therapeutics

, 2022
In the clinical setting, the pathophysiology of sensorineural hearing loss is poorly defined and there are currently no diagnostic tests available to differentiate between subtypes.
Hinrich Staecker, Madeleine St. Peter, Athanasia Warnecke   +2 more
core   +1 more source

Are there morpho‐acoustic patterns of adaptation in nonhuman primate ears? Testing the role of ecology and habitat in shaping ear morphology and function

The Anatomical Record, EarlyView.
Abstract Analysis of the variation in the bony structures of the inner and middle ear provides critical insights into functional morphology, as well as adaptive morphology across primates. In this study, we investigated whether ear morphology patterns are related to the ecological characteristics of species and their habitats to test two acoustic ...
Myriam Marsot, Rémi Laffont, Émilie Steimetz, Patricia Balaresque, Sébastien Couette   +4 more
wiley   +1 more source

Personalized Proteomics for Precision Diagnostics in Hearing Loss: Disease-Specific Analysis of Human Perilymph by Mass Spectrometry

, 2021
Despite a vast amount of data generated by proteomic analysis on cochlear fluid, novel clinically applicable biomarkers of inner ear diseases have not been identified hitherto.
Andreas Pich, Martin Durisin, Heike A. Schmitt, Hinrich Staecker, Athanasia Warnecke, Jennifer Harre (10287764), Hinrich Staecker (6507986), Jennifer Harre, Heike A. Schmitt (3924209), Thomas Lenarz, Nils K. Prenzler (6873197), Thomas Lenarz (491685), Martin Durisin (538612), Athanasia Warnecke (496575), Nils K. Prenzler, Andreas Pich (152212)   +15 more
core   +2 more sources

Calcium-Sensing Receptor Is Functionally Expressed in the Cochlear Perilymphatic Compartment and Essential for Hearing

Frontiers in Molecular Neuroscience, 2019
Maintaining Ca2+ homeostasis in lymphatic fluids is necessary for proper hearing. Despite its significance, the mechanisms that maintain the cochlear lymphatic Ca2+ concentrations within a certain range are not fully clarified.
Toshiya Minakata, Akira Inagaki, Aya Yamamura, Hisao Yamamura, Shinji Sekiya, Shingo Murakami   +5 more
doaj   +1 more source