Isosorbide Concentration in Perilymph of the Guinea Pig After Oral Administration Versus That After Round Window Perfusion [PDF]
Clinical and Experimental Otorhinolaryngology, 2014 ObjectivesThe aims of this study were to investigate the feasibility of isosorbide delivery into perilymph through the round window membrane (RWM), and to compare the intracochlear isosorbide concentration in perilymph after oral administration (PO ...
Minbum Kim, Kyung Hee Do, Kyu-Sung Kim
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Pharmacokinetics of sodium thiosulfate in Guinea pig perilymph following middle ear application
Journal of Otology, 2018 Hypothesis: To determine the pharmacokinetics of sodium thiosulfate in the inner ear perilymph following middle ear application in Guinea pigs. Background: Cisplatin chemotherapy is often associated with a dose-dependent high frequency sensorineural ...
Ronald J. Schroeder, II +3 more
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PLoS ONE, 2022 Modern proteomic analysis and reliable surgical access to gain liquid inner ear biopsies have enabled in depth molecular characterization of the cochlea microenvironment.
Martin Durisin +8 more
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Detection of BDNF-Related Proteins in Human Perilymph in Patients With Hearing Loss [PDF]
Frontiers in Neuroscience, 2019 The outcome of cochlear implantation depends on multiple variables including the underlying health of the cochlea. Brain derived neurotrophic factor (BDNF) has been shown to support spiral ganglion neurons and to improve implant function in animal models.
Ines de Vries +10 more
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The proteome of perilymph in patients with vestibular schwannoma. A possibility to identify biomarkers for tumor associated hearing loss? [PDF]
PLoS ONE, 2018 BACKGROUND:Due to the surrounding bone, the human inner ear is relatively inaccessible and difficult to reach for cellular and molecular analyses. However, these types of investigations are needed to better understand the etiology, pathophysiology and ...
Jesper Edvardsson Rasmussen +4 more
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Journal of Otology, 2020 Objectives: To evaluate the pathological changes in the blood-perilymph, blood-endolymph, and blood-nerve barriers of a patient with idiopathic sudden sensorineural hearing loss (SSNHL).
Jing Zou
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The diagnostic performance of a novel ELISA for human CTP (Cochlin-tomoprotein) to detect perilymph leakage. [PDF]
PLoS ONE, 2018 Perilymphatic fistula is defined as an abnormal communication between the perilymph-filled space and the middle ear, or cranial spaces. The manifestations include a broad spectrum of neuro-otological symptoms such as hearing loss, vertigo/dizziness ...
Tetsuo Ikezono +16 more
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Vestibule-Middle Ear Dehiscence Tested With Perilymph-Specific Protein Cochlin-Tomoprotein (CTP) Detection Test [PDF]
Frontiers in Neurology, 2019 An 8-year-old boy was referred to the ENT department for further evaluation of right-sided conductive hearing loss. A small cyst anterior to the oval window and fixation of the stapes footplate were observed during an exploratory tympanotomy.
Takeshi Fujita +5 more
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Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs. [PDF]
PLoS ONE, 2017 Patients undergoing cochlear implantation could benefit from a simultaneous application of drugs into the ear, helping preserve residual low-frequency hearing and afferent nerve fiber populations.
Alec Salt +5 more
doaj +3 more sources
Significance of Pseudo-Conductive Hearing Loss and Positional Nystagmus for Perilymphatic Fistula: Are They Related to Third-Window Effects? [PDF]
Clinical and Experimental Otorhinolaryngology, 2021 Objectives Patients’ clinical presentation is critical for identifying suspected perilymphatic fistula (PLF). The involvement of third-window lesions in the pathomechanism of PLF has been hypothesized. This study investigated the clinical features of PLF
Jong Sei Kim +4 more
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