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Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas
Frontiers in Cell and Developmental Biology, 2022 The high complexity of the cellular architecture of the human inner ear and the inaccessibility for tissue biopsy hampers cellular and molecular analysis of inner ear disease.
Alina van Dieken +8 more
doaj +1 more source
BMC Medical Imaging, 2021 Background Non-contrast FLAIR revealed increased signal within the inner ear in patients with vestibular schwannoma, which is generally assumed to occur in the perilymph; however, the majority of previous studies did not differentiate between the ...
Iichiro Osawa +7 more
doaj +1 more source
Frontiers in Neurology, 2022 We evaluated the inner ear distribution of 17O-labeled saline administered to the human tympanic cavity. Magnetic resonance imaging was performed after intratympanic administration in five healthy volunteers and one patient with cochlear endolymphatic ...
Tadao Yoshida +10 more
doaj +1 more source
Table1_Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas.DOCX [PDF]
, 2022 The high complexity of the cellular architecture of the human inner ear and the inaccessibility for tissue biopsy hampers cellular and molecular analysis of inner ear disease.
Hinrich Staecker (6507986) +8 more
core +1 more source
Major protein categories in human perilymph. [PDF]
, 2019 (A) The perilymph of patients with intact hearing. Within each category, the percentage of the total amount of proteins is denoted within each bar. The Other category included proteins involved in ubiquitination, blood coagulation cascade, and receptors.
Yin Ren (550805) +4 more
core +1 more source
Proteome of Human Perilymph [PDF]
Journal of Proteome Research, 2011 Current diagnostic tools limit a clinician's ability to discriminate between many possible causes of sensorineural hearing loss. This constraint leads to the frequent diagnosis of the idiopathic condition, leaving patients without a clear prognosis and only general treatment options.
Andrew C, Lysaght +5 more
openaire +2 more sources
Proteomic analysis of human perilymph. [PDF]
, 2019 (A) Principal component analysis (PCA) of the normalized and log-transformed spectral count matrix from the 6 samples of perilymph, including 3 from patients with normal hearing (pseudocolored green) and 3 from patients with severe vestibular dysfunction
Yin Ren (550805) +4 more
core +1 more source
Sonoporation of the Round Window Membrane on a Sheep Model: A Safety Study
Pharmaceutics, 2023 Sonoporation using microbubble-assisted ultrasound increases the permeability of a biological barrier to therapeutic molecules. Application of this method to the round window membrane could improve the delivery of therapeutics to the inner ear.
Sandrine Kerneis +10 more
doaj +1 more source
Proteome of Human Perilymph [PDF]
, 2016 Current diagnostic tools limit a clinician’s ability to discriminate between many possible causes of sensorineural hearing loss. This constraint leads to the frequent diagnosis of the idiopathic condition, leaving patients without a clear prognosis and ...
Saumil N. Merchant (2172880) +5 more
core +1 more source
A Window of Opportunity: Perilymph Sampling from the Round Window Membrane Can Advance Inner Ear Diagnostics and Therapeutics [PDF]
, 2022 In the clinical setting, the pathophysiology of sensorineural hearing loss is poorly defined and there are currently no diagnostic tests available to differentiate between subtypes.
Hinrich Staecker +2 more
core +1 more source