Results 21 to 30 of about 5,505 (208)

A Novel Drug-Loaded Porous Parylene Electrode for Targeted Anti-Inflammatory Therapy and Hearing Preservation in Cochlear Implantation. [PDF]

Adv Healthc Mater
A porous parylene‐coated electrode loaded with dexamethasone was developed to reduce inflammation after cochlear implantation. In guinea pigs, the device provided sustained drug release, maintained biocompatibility, improved auditory brainstem response thresholds, and reduced inflammatory cell infiltration and TNF‐α expression.
Chang CC, Lu YC, Chang YM, Chan YH, Yan HY, Lee YS, Lin PH, Hsieh CY, Hsu CJ, Liu TC, Chen HY, Wu CC.   +11 more
europepmc   +2 more sources

Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas

Frontiers in Cell and Developmental Biology, 2022
The high complexity of the cellular architecture of the human inner ear and the inaccessibility for tissue biopsy hampers cellular and molecular analysis of inner ear disease.
Alina van Dieken, Hinrich Staecker, Heike Schmitt, Jennifer Harre, Andreas Pich, Willi Roßberg, Thomas Lenarz, Martin Durisin, Athanasia Warnecke   +8 more
doaj   +1 more source

Signal and morphological changes in the endolymph of patients with vestibular schwannoma on non-contrast 3D FLAIR at 3 Tesla

BMC Medical Imaging, 2021
Background Non-contrast FLAIR revealed increased signal within the inner ear in patients with vestibular schwannoma, which is generally assumed to occur in the perilymph; however, the majority of previous studies did not differentiate between the ...
Iichiro Osawa, Eito Kozawa, Sayuri Tanaka, Akane Kaizu, Kaiji Inoue, Tetsuo Ikezono, Takamitsu Fujimaki, Mamoru Niitsu   +7 more
doaj   +1 more source

17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function

Frontiers in Neurology, 2022
We evaluated the inner ear distribution of 17O-labeled saline administered to the human tympanic cavity. Magnetic resonance imaging was performed after intratympanic administration in five healthy volunteers and one patient with cochlear endolymphatic ...
Tadao Yoshida, Shinji Naganawa, Masumi Kobayashi, Satofumi Sugimoto, Naomi Katayama, Tsutomu Nakashima, Yutaka Kato, Kazushige Ichikawa, Hiroshi Yamaguchi, Kazuki Nishida, Michihiko Sone   +10 more
doaj   +1 more source

Dual viscosity mixture vehicle for intratympanic steroid treatment modifies the ROS and inflammation related proteomes

Frontiers in Pharmacology, 2023
Until recently, the most standard treatment for sensorineural or sudden hearing loss, which is caused by inner ear damage or deterioration, has been systemic oral steroid administration.
Jin Woo Jung, Hui Li, Jung Hun Lee, Yu-Jung Hwang, Kisoon Dan, Moo Kyun Park, Dohyun Han, Dohyun Han, Myung-Whan Suh   +8 more
doaj   +1 more source

Long-Term in vivo Release Profile of Dexamethasone-Loaded Silicone Rods Implanted Into the Cochlea of Guinea Pigs

Frontiers in Neurology, 2020
Glucocorticoids are used intra-operatively in cochlear implant surgeries to reduce the inflammatory reaction caused by insertion trauma and the foreign body response against the electrode carrier after cochlear implantation.
Arne Liebau, Sören Schilp, Kenneth Mugridge, Ilona Schön, Michel Kather, Michel Kather, Bernd Kammerer, Jochen Tillein, Susanne Braun, Stefan K. Plontke   +9 more
doaj   +1 more source

Table1_Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas.DOCX

, 2022
The high complexity of the cellular architecture of the human inner ear and the inaccessibility for tissue biopsy hampers cellular and molecular analysis of inner ear disease.
Hinrich Staecker (6507986), Heike Schmitt (463610), Willi Roßberg (12472461), Alina van Dieken (12472458), Thomas Lenarz (491685), Martin Durisin (538612), Athanasia Warnecke (496575), Jennifer Harre (10287764), Andreas Pich (152212)   +8 more
core   +1 more source

Metabolomic Studies in Inner Ear Pathologies

Metabolites, 2022
Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired.
Luc Boullaud, Hélène Blasco, Thuy-Trân Trinh, David Bakhos   +3 more
doaj   +1 more source

Sonoporation of the Round Window Membrane on a Sheep Model: A Safety Study

Pharmaceutics, 2023
Sonoporation using microbubble-assisted ultrasound increases the permeability of a biological barrier to therapeutic molecules. Application of this method to the round window membrane could improve the delivery of therapeutics to the inner ear.
Sandrine Kerneis, Jean-Michel Escoffre, John J. Galvin, Ayache Bouakaz, Antoine Presset, Corentin Alix, Edward Oujagir, Antoine Lefèvre, Patrick Emond, Hélène Blasco, David Bakhos   +10 more
doaj   +1 more source

Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear

Frontiers in Cellular Neuroscience, 2019
Some forms of triamcinolone may provide alternate options for local therapy of the inner ear in addition to the steroids currently in use. We compared the perilymph pharmacokinetics of triamcinolone-acetonide, triamcinolone, and dexamethasone, each ...
Alec Nicholas Salt, Jared James Hartsock, Jennifer Hou, Fabrice Piu   +3 more
doaj   +1 more source