Results 101 to 110 of about 1,483 (262)
Advanced Science, EarlyView.In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu +7 more
wiley +1 more source
Iron‐Mediated Release of Aged Dissolved Organic Carbon From Waterlogged Peatland Under Warming
Advanced Science, EarlyView.This study conducts a five‐year in situ warming experiment in high‐altitude peatlands to examine dissolved organic carbon (DOC) release. The study shows that warming promotes the release of plant‐derived modern DOC in drained peatlands, but amplifies aquatic export of century‐old DOC from waterlogged peatlands via Fe‐mediated DOC mobilization—a ...
Guohua Dai +18 more
wiley +1 more source
Advanced Science, EarlyView.A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa +8 more
wiley +1 more source
Applied SciencesRoundabouts are widely used in road transport to improve traffic flow and reduce congestion by enabling continuous movement in a circular pattern, minimizing stops, enhancing safety, and reducing delays compared to that of signaled intersections. However,
Joe Ronald Kurniawan Bokau +4 more
doaj +1 more source
PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes
Advanced Science, EarlyView.A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li +10 more
wiley +1 more source
Advanced Science, EarlyView.A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu +9 more
wiley +1 more source
An Energy Autonomous Microneedle Array‐Based Sensing System for Continuous Biomarker Monitoring
Advanced Science, EarlyView.This work presents an innovative self‐powered wearable biosensor system for real‐time monitoring of multiple biomarkers in interstitial fluid. The device integrates stainless steel‐based minimally invasive microneedles with ion‐selective membranes, enabling simultaneous Na+, K+, Ca2+, pH, and glucose detection.
Arnab Pal +9 more
wiley +1 more source
Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs
Advanced Science, EarlyView.Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan +7 more
wiley +1 more source
Exploration of the application of Grey-Markov models in the causality analysis of traffic accidents in roundabouts. [PDF]
PLoS One, 2023 Li P, Li J.
europepmc +1 more source