Results 141 to 150 of about 1,473 (259)

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Evaluating pedestrian crossing safety: Implementing and evaluating a convolutional neural network model trained on paired aerial and subjective perspective images. [PDF]

Heliyon
Russon D, Guennec A, Naredo-Turrado J, Xu B, Boussuge C, Battaglia V, Hiron B, Lagarde E.   +7 more
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

A Three-Stage Cellular Automata Model of Complex Large Roundabout Traffic Flow, with a Flow-Efficiency- and Safety-Enhancing Strategy. [PDF]

Sensors (Basel)
Liang X, Xie CT, Song HF, Guo YJ, Peng JX.   +4 more
europepmc   +1 more source

Nanopore‐Based Protein Deceleration and Sensing Using Graphene/Si3N4 Dual Membrane Cavity

Advanced Science, EarlyView.
A graphene/Si3N4 dual membrane cavity system achieves multi‐stage protein deceleration through spatial geometry. Multi‐level current traces provide high‐resolution spatial localization and early warning signals. ABSTRACT Sequencing of protein with nanopores has emerged as a powerful tool offering rapid readout, high accuracy, low cost, and portability.
Yubin Cao, Junzhou He, Wei Si
wiley   +1 more source

Optimized path planning and scheduling strategies for connected and automated vehicles at single-lane roundabouts. [PDF]

PLoS One
Wang L, Liang H, Jian Y, Luo Q, Gong X, Zhang Y.   +5 more
europepmc   +1 more source

Editorial for the Special Issue on Network on Chip (NoC) and Reconfigurable Systems. [PDF]

Micromachines (Basel), 2023
Zitouni A.
europepmc   +1 more source

Interfacial Water Coordination on Ruthenium Oxide Nanoparticles Confined Within Covalent Organic Framework and Its Effect on Electrochemical Nitrate Reduction

Advanced Science, EarlyView.
We demonstrate how oxygen‐deficient ruthenium oxide (RuOx) nanoparticles confined within covalent organic framework achieve highly efficient nitrate‐to‐ammonia conversion. Strong interaction between RuOx nanoparticles and COF results in modified interfacial hydrogen‐bond water network and adsorption of nitrogenous intermediates.
Yun Li, Xin Zhao, Arsenii S. Portniagin, Yuxuan Wu, Desui Chen, Haochen Liu, Andrey L. Rogach   +6 more
wiley   +1 more source

Risk Assessment of Roundabout Scenarios in Virtual Testing Based on an Improved Driving Safety Field. [PDF]

Sensors (Basel)
Chen W, Li A, Jiang H.
europepmc   +1 more source

Temporal variations in air pollution at two roundabouts in the city of Cotonou (Benin). [PDF]

J Public Health Res, 2021
Codjo-Seignon LMK, Houssou VMC, Kossolou P, Sopoh GE, Aina MP.   +4 more
europepmc   +1 more source