Results 51 to 60 of about 23,696 (245)

Efficacy and Safety of Retinol Palmitate Ophthalmic Solution in the Treatment of Dry Eye: A Japanese Phase II Clinical Trial [Corrigendum]

Drug Design, Development and Therapy, 2021
Toshida H, Funaki T, Ono K, et al. Drug Des Devel Ther.  2017;11:1871– 1879 The authors have advised there are some mistakes in the mean changes and standard errors of the paper: 1.
Toshida H, Funaki T, Ono K, Tabuchi N, Watanabe S, Seki T, Otake H, Kato T, Ebihara N, Murakami A   +9 more
doaj  

Human semen quality and the secondary sex ratio

Asian Journal of Andrology, 2017
The aim of this study was to evaluate the association between semen quality and the secondary sex ratio (SSR), defined as the ratio of male to female live births.
Jisuk Bae, Sungduk Kim, Zhen Chen, Michael L Eisenberg, Germaine M Buck Louis   +4 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Optimization of Multi-Section and Partially Augmented Magnetic Resonance Imaging (MRI) Images for Brain Tumor Classification Using ResNet-50

CommIT Journal
Brain tumor diagnosis is challenging due to complex brain anatomy and tumor variability across imaging views. Traditional methods are manual and error-prone, making deep learning, particularly ResNetbased Convolutional Neural Network (CNN), essential ...
I Gede Susrama Mas Diyasa, Victor Immanuel Sunarko, Eva Yulia Puspaningrum, Vaizal Asy'ari, Mohd Zamri Ibrahim   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Novel Approximate Floating-Point Adder With Runtime Tunable Precision

IEEE Access
This paper proposes a novel low-power approximate floating-point adder with runtime configurable precision. The design combines skipping addition, triggered when the exponent difference exceeds a programmable threshold, with tunable mantissa rounding to ...
Luca Tegazzini, Gennaro Di Meo, Aldo Torino, Francesco Del Prete, Davide de Caro, Claudio Parrella, Antonio Giuseppe Maria Strollo   +6 more
doaj   +1 more source

Aproximación numérica del modelo epidemiológico SI para la propagación de gusanos informáticos, simulación y análisis de su error

Tecnura, 2014
In the biological environment, there has been created epidemiological models that attempt to explain the spread dynamics of an epidemic in a population to predict the behavior of possible epidemics that can affect humanity.
Pedro Guevara López, Jorge Salvador Valdez Martínez , Jesús Audelo González, Gustavo Delgado Reyes   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source