Results 71 to 80 of about 34,561 (298)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Fast And Simple NEMO Authentication Via Random Number. [PDF]

open access: yes, 2007
Network Mobility (NEMO), derived from Mobile Internet Protocol version 6 (MIFV6) technology, has been evolving and expanding in very rapidity manner across very short period of time.
Samsudin, Azman, Tan, Tat Kin
core   +1 more source

Method for router online security risk assessment quantification

open access: yesTongxin xuebao, 2013
The concept of router safety performance was proposed based on the nature of router security issues and router attacks were classified. Then a method for router online security risk assessment quantification was also presented.The security risk factor of
Jun-gang YANG   +4 more
doaj  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Push based buffer setting strategy for high density linecard of small buffer size

open access: yesTongxin xuebao, 2008
Much of the previous work on buffer design of router linecard mainly focus on how to implement large and fast packet buffers,however,lots of recent theories suggest that the optimal buffer size would no longer be a large one as expected,and a small ...
LI Yu-feng1   +3 more
doaj  

PERFORMANCE REQUIRED FOR COMMON-USE COMPONENTS OF COMPUTER NETWORKS

open access: yesJournal of Engineering Science (Chişinău)
Sometimes, in practice, simple solutions of quick preliminary estimation of basic characteristics of a computer network are needed.In this aim, the backbone subnet and server set of wide area computer networks are examined.
BOLUN, Ion
doaj   +1 more source

The Mechanism of Burr Inhibition for Milling CFRP with New Type of Milling Tools

open access: yesJournal of Harbin University of Science and Technology, 2018
Concerning the machining defects such as burrs while milling Carbon Fiber-reinforced Plastics( CFRP) with ordinary cutters,the cutting mechanism of the new-type end mills for suppressing the burrs generation in milling CFRP was analyzed.
YANG Xiao-fan   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Novel wobble-defended M-MULTOPS structure and its application in detecting network abnormal traffic

open access: yesTongxin xuebao, 2007
A new detection method: wobble defended M-MULTOPS(modified-multi-level tree for online packet statistics) structure was presented.Aiming at the change of network traffic in core routers,ABF(adapted bloom filter) algorithm to assemble destination ...
SUN Zhi-xin1, TANG Yi-wei1, GONG Jing1
doaj  

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